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  • We previously reported that therapy of human cervical carcinoma HeLa cells with CP induced segregation of nucleoli and changes of nuclei characteristic of apoptosis. We raised the question of whether p53 can be reactivated by chemotherapy in HeLa cells despite the presence of HPV-encoded E6 activity. Since the reduced stability of wild-type p53 protein in HeLa cells is a consequence of its enhanced ubiquitination by virally encoded E6 protein, resulting in its accelerated degradation, we checked the cellular level of E6 during CP therapy. Six hours after application of CP, E6 protein expression was markedly reduced. This coincided with the increase of cellular p53 and preceded the nucleolar accumulation of p53 protein, indicating that repression of virally coded E6 protein by CP contributes to the restoration of p53 expression.
  • We previously reported that therapy of human cervical carcinoma HeLa cells with CP induced segregation of nucleoli and changes of nuclei characteristic of apoptosis. We raised the question of whether p53 can be reactivated by chemotherapy in HeLa cells despite the presence of HPV-encoded E6 activity. Since the reduced stability of wild-type p53 protein in HeLa cells is a consequence of its enhanced ubiquitination by virally encoded E6 protein, resulting in its accelerated degradation, we checked the cellular level of E6 during CP therapy. Six hours after application of CP, E6 protein expression was markedly reduced. This coincided with the increase of cellular p53 and preceded the nucleolar accumulation of p53 protein, indicating that repression of virally coded E6 protein by CP contributes to the restoration of p53 expression. (en)
Title
  • Escape of p53 protein from E6-mediated degradation in HeLa cells after cisplatin therapy
  • Escape of p53 protein from E6-mediated degradation in HeLa cells after cisplatin therapy (en)
skos:prefLabel
  • Escape of p53 protein from E6-mediated degradation in HeLa cells after cisplatin therapy
  • Escape of p53 protein from E6-mediated degradation in HeLa cells after cisplatin therapy (en)
skos:notation
  • RIV/00216224:14110/02:00007250!RIV/2003/MSM/141103/N
http://linked.open.../vavai/riv/strany
  • 128
http://linked.open...avai/riv/aktivita
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http://linked.open...iv/cisloPeriodika
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http://linked.open...dnocenehoVysledku
  • 645258
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/02:00007250
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • apoptosis, nucleolar segregation, E6, cisplatin, PARP-1 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [637524857387]
http://linked.open...i/riv/nazevZdroje
  • International Journal of Cancer
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 101
http://linked.open...iv/tvurceVysledku
  • Wesierska-Gadek, Jozefa
  • Horký, Marcel
  • Kotala, Vladimír
  • Schloffer, Daniela
http://linked.open...n/vavai/riv/zamer
issn
  • 0020-7136
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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