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  • Our previous experiments with sigma receptor ligands in rat myocytes and rat isolated hearts suggested that these receptors may play a role in modulation of contractility. The aim of the present study was to examine the effect of sigma ligand haloperidol in the multicellular guinea pig heart preparations. The effects of haloperidol on the amplitude of contraction and on the restitution of contractility were investigated. The positive inotropic effect of haloperidol was confirmed also in guinea pig atrial preparations. According to its effect on the mechanical restitution we can assume that it is mediated via increased cytoplasmatic Ca2+concentration.
  • Our previous experiments with sigma receptor ligands in rat myocytes and rat isolated hearts suggested that these receptors may play a role in modulation of contractility. The aim of the present study was to examine the effect of sigma ligand haloperidol in the multicellular guinea pig heart preparations. The effects of haloperidol on the amplitude of contraction and on the restitution of contractility were investigated. The positive inotropic effect of haloperidol was confirmed also in guinea pig atrial preparations. According to its effect on the mechanical restitution we can assume that it is mediated via increased cytoplasmatic Ca2+concentration. (en)
  • Our previous experiments with sigma receptor ligands in rat myocytes and rat isolated hearts suggested that these receptors may play a role in modulation of contractility. The aim of the present study was to examine the effect of sigma ligand haloperidol in the multicellular guinea pig heart preparations. The effects of haloperidol on the amplitude of contraction and on the restitution of contractility were investigated. The positive inotropic effect of haloperidol was confirmed also in guinea pig atrial preparations. According to its effect on the mechanical restitution we can assume that it is mediated via increased cytoplasmatic Ca2+concentration. (cs)
Title
  • The Effect of Sigma Ligand Haloperidol in Guinea Pig Atrial Preparation
  • The Effect of Sigma Ligand Haloperidol in Guinea Pig Atrial Preparation (en)
  • The Effect of Sigma Ligand Haloperidol in Guinea Pig Atrial Preparation (cs)
skos:prefLabel
  • The Effect of Sigma Ligand Haloperidol in Guinea Pig Atrial Preparation
  • The Effect of Sigma Ligand Haloperidol in Guinea Pig Atrial Preparation (en)
  • The Effect of Sigma Ligand Haloperidol in Guinea Pig Atrial Preparation (cs)
skos:notation
  • RIV/00216224:14110/02:00006987!RIV08-GA0-14110___
http://linked.open.../vavai/riv/strany
  • 29P
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA102/01/1494)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 644314
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/02:00006987
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • guinea pig; atrium; sigma receptor; haloperidol; mechanical restitution (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [0E035FEACB8A]
http://linked.open...i/riv/nazevZdroje
  • Physiological Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 51
http://linked.open...iv/tvurceVysledku
  • Nováková, Marie
issn
  • 0862-8408
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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