About: Isolation of monoclonal immunoglobulin from plasma of patients with multople myeloma using affinity chromatography

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Multiple myeloma is characterized by the proliferation of a malignant plasma cell clone and accounts for approximately 10% of hematological malignancies. High-dose chemotherapy with autologous transplantation has improved the survival of patients with myeloma, hovewer, relapse is inevitable (1,2). Recent research has targeted the minimal residual disease. One of the therapeutical options is this setting is immunotherapy using specific tumor antigen as a vaccine. The idiotype of myeloma immunoglobulin (Id protein) is specifically expressed by malignant cells and can be used as a tumor antigen with the aim to induce cytotoxic T-lymphocyte response against myeloma cells (3,4,5,6). For purification of Id protein from plasma of relapsed IgG myeloma patients who were before reinduction treatment, plasma was precipitated with a saturated solution of ammonium sulfate. After precipitation and dialysis in saline at pH 7.3 to remove ammonium sulfate, the Id protein was separated on protein G immobilized on agar Multiple myeloma is characterized by the proliferation of a malignant plasma cell clone and accounts for approximately 10% of hematological malignancies. High-dose chemotherapy with autologous transplantation has improved the survival of patients with myeloma, hovewer, relapse is inevitable (1,2). Recent research has targeted the minimal residual disease. One of the therapeutical options is this setting is immunotherapy using specific tumor antigen as a vaccine. The idiotype of myeloma immunoglobulin (Id protein) is specifically expressed by malignant cells and can be used as a tumor antigen with the aim to induce cytotoxic T-lymphocyte response against myeloma cells (3,4,5,6). For purification of Id protein from plasma of relapsed IgG myeloma patients who were before reinduction treatment, plasma was precipitated with a saturated solution of ammonium sulfate. After precipitation and dialysis in saline at pH 7.3 to remove ammonium sulfate, the Id protein was separated on protein G immobilized on agar (en)
Title	Isolation of monoclonal immunoglobulin from plasma of patients with multople myeloma using affinity chromatography Isolation of monoclonal immunoglobulin from plasma of patients with multople myeloma using affinity chromatography (en)
skos:prefLabel	Isolation of monoclonal immunoglobulin from plasma of patients with multople myeloma using affinity chromatography Isolation of monoclonal immunoglobulin from plasma of patients with multople myeloma using affinity chromatography (en)
skos:notation	RIV/00216224:14110/02:00006850!RIV/2003/MZ0/141103/N
http://linked.open.../vavai/riv/strany	223
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NC6763)
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Penka, Miroslav Táborská, Eva Büchler, Tomáš Hájek, Roman Bourková, Ludmila Musilová, Romana
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	649798
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/02:00006850
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	multiple myeloma, IgG, affinity chromatography, G-protein (en)
http://linked.open.../riv/klicoveSlovo	G-protein multiple myeloma affinity chromatography IgG
http://linked.open...ontrolniKodProRIV	[47979D855266]
http://linked.open...v/mistoKonaniAkce	10.-13.9.2002 Stará lesná
http://linked.open...i/riv/mistoVydani	Bratislava, SR
http://linked.open...i/riv/nazevZdroje	Zborník XVII.Biochemický zjazd
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Use of monoclonal immunoglobulin for preparation of antitumor vaccine in patients with multiple myeloma
http://linked.open...UplatneniVysledku	2002
http://linked.open...iv/tvurceVysledku	Hájek, Roman Penka, Miroslav Táborská, Eva Büchler, Tomáš Bourková, Ludmila Kovářová, L. Novotná, H. Musilová, Romana
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2002-01-01 (xsd:date)
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	VEDA, vydavatelstvo SAV, Bratislava
http://localhost/t...ganizacniJednotka	14110

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