About: MASS SPECTROMETRY OF 1,3- AND 1,5-DICAFFEOYLQUINIC ACIDS

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The polyphenolic compound 1, also known as cynarin, is of interest biomedically because of its hypocholesterolemic, hepatoprotective and antioxidant activity.1 The dicaffeoylquinic acids (DCQAs), in general, show a number of pharmacological actions, with the most important being anti-HIV activity. The DCQAs have recently been recognized as an important class of HIV-integrase inhibitors and, thus, prevent insertion of viral DNA into the host genome, and essential step in the replication of the virus. The DCQAs strongly and irreversibly inhibit HIV-1 integration in biochemical assays and block viral replication at non-toxic concentrations. Earlier studies2 showed that the peracetate derivatives of 3 and 4 displayed greater anti-HIV activity than the free compounds and that the activity of peracetyl-3 approaches that of AZT. Thus, there is considerable biomedical interest in the DCQAs and selected derivatives of the DCQAs. Obtaining quantities of pure 1 has been difficult. Extraction from plant ma The polyphenolic compound 1, also known as cynarin, is of interest biomedically because of its hypocholesterolemic, hepatoprotective and antioxidant activity.1 The dicaffeoylquinic acids (DCQAs), in general, show a number of pharmacological actions, with the most important being anti-HIV activity. The DCQAs have recently been recognized as an important class of HIV-integrase inhibitors and, thus, prevent insertion of viral DNA into the host genome, and essential step in the replication of the virus. The DCQAs strongly and irreversibly inhibit HIV-1 integration in biochemical assays and block viral replication at non-toxic concentrations. Earlier studies2 showed that the peracetate derivatives of 3 and 4 displayed greater anti-HIV activity than the free compounds and that the activity of peracetyl-3 approaches that of AZT. Thus, there is considerable biomedical interest in the DCQAs and selected derivatives of the DCQAs. Obtaining quantities of pure 1 has been difficult. Extraction from plant ma (en)
Title	MASS SPECTROMETRY OF 1,3- AND 1,5-DICAFFEOYLQUINIC ACIDS MASS SPECTROMETRY OF 1,3- AND 1,5-DICAFFEOYLQUINIC ACIDS (en)
skos:prefLabel	MASS SPECTROMETRY OF 1,3- AND 1,5-DICAFFEOYLQUINIC ACIDS MASS SPECTROMETRY OF 1,3- AND 1,5-DICAFFEOYLQUINIC ACIDS (en)
skos:notation	RIV/00216224:14110/01:00004265!RIV/2002/GA0/141102/N
http://linked.open.../vavai/riv/strany	67
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA303/00/D062)
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Táborská, Eva Slanina, Jiří
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	686005
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/01:00004265
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mass spectrometry, isomers, dicaffeoylquinic acids (en)
http://linked.open.../riv/klicoveSlovo	dicaffeoylquinic acids mass spectrometry isomers
http://linked.open...ontrolniKodProRIV	[00EC00B9572F]
http://linked.open...v/mistoKonaniAkce	Chicago
http://linked.open...i/riv/mistoVydani	Chicago
http://linked.open...i/riv/nazevZdroje	49th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Bioavailability and mechanism of antioxidant activity of phenolic acids and lignans
http://linked.open...UplatneniVysledku	2001
http://linked.open...iv/tvurceVysledku	Táborská, Eva Slanina, Jiří Miketová, Petra Schram, Karl H.
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2001-01-01 (xsd:date)
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	American Society for Mass Spectrometry
http://localhost/t...ganizacniJednotka	14110

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