About: New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A facile and inexpensive preparation of 1,3-dicaffeoylquinic acid (cynarin) from the leaves Cynara cardunculus L. (Asteraceae) without the use any chromatographic steps is described. The procedure was based on separation of the fraction rich in 1,5-dicaffeoylquinic acid, isomerisation of 1,5-dicaffeoylquinic acid to cynarin and, owing to its higher polarity, the simple isolation of cynarin from the reaction mixture. Cynarin inhibited HIV-1 replication in MT-2 cell culture at nontoxic concentrations similar to other previously tested dicaffeoylquinic acids, which have been recently established as a potent and highly selective class of HIV-1 integrase inhibitors. A facile and inexpensive preparation of 1,3-dicaffeoylquinic acid (cynarin) from the leaves Cynara cardunculus L. (Asteraceae) without the use any chromatographic steps is described. The procedure was based on separation of the fraction rich in 1,5-dicaffeoylquinic acid, isomerisation of 1,5-dicaffeoylquinic acid to cynarin and, owing to its higher polarity, the simple isolation of cynarin from the reaction mixture. Cynarin inhibited HIV-1 replication in MT-2 cell culture at nontoxic concentrations similar to other previously tested dicaffeoylquinic acids, which have been recently established as a potent and highly selective class of HIV-1 integrase inhibitors. (en) Nová a snadná metoda přípravy anti-HIV-1 činidla, 1,3-dicaffeoylchinové kyseliny je popsána (cs)
Title	Nová a snadná metoda přípravy anti-HIV-1 činidla, 1,3-dicaffeoylchinové kyseliny (cs) New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid (en)
skos:prefLabel	Nová a snadná metoda přípravy anti-HIV-1 činidla, 1,3-dicaffeoylchinové kyseliny (cs) New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid (en)
skos:notation	RIV/00216224:14110/01:00004264!RIV09-GA0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA303/00/D062)
http://linked.open...iv/cisloPeriodika	19
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Táborská, Eva Slaninová, Iva Bochořáková, Hana Slanina, Jiří Humpa, Otakar
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	688708
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/01:00004264
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Antivirals; biologically active compounds; isomerisation; phenolics; tannins (en)
http://linked.open.../riv/klicoveSlovo	phenolics isomerisation biologically active compounds tannins Antivirals
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[ED588889DE57]
http://linked.open...i/riv/nazevZdroje	Tetrahedron Letters
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Bioavailability and mechanism of antioxidant activity of phenolic acids and lignans
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	42
http://linked.open...iv/tvurceVysledku	Slaninová, Iva Táborská, Eva Slanina, Jiří Humpa, Otakar Bochořáková, Hana Schram, Karl H. Robinson, W. Edward
http://linked.open...ain/vavai/riv/wos	000168404000036
issn	0040-4039
number of pages	3385 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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