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  • Abstract. The ability of baicalin, the flavonoid from the roots of the medicinal plant Scutellaria baicalensis, to scavenge hydroxyl radicals was studied with using sensitive HPLC method. The hydroxyl radicals were generated by UV photolysis of H2O2 and salicylic acid was used as a trapping agent. The hydroxylation products of salicylic acid, 2,3- and 2,5- dihydroxybenzoic acids, were detected by HPLC. Baicalin caused decrease in the production of 2,3- and 2,5 - dihydroxybenzoic acid in a concentration dependent manner and did not affect peaks of the standard of these dihydroxybenzoic acids. These results indicate that baicalin scavenges hydroxyl radicals generated by UV photolysis of H2O2. IC(50) values were estimated.
  • Abstract. The ability of baicalin, the flavonoid from the roots of the medicinal plant Scutellaria baicalensis, to scavenge hydroxyl radicals was studied with using sensitive HPLC method. The hydroxyl radicals were generated by UV photolysis of H2O2 and salicylic acid was used as a trapping agent. The hydroxylation products of salicylic acid, 2,3- and 2,5- dihydroxybenzoic acids, were detected by HPLC. Baicalin caused decrease in the production of 2,3- and 2,5 - dihydroxybenzoic acid in a concentration dependent manner and did not affect peaks of the standard of these dihydroxybenzoic acids. These results indicate that baicalin scavenges hydroxyl radicals generated by UV photolysis of H2O2. IC(50) values were estimated. (en)
  • Pomocí HPLC byla studována schopnost bajkalinu, flavonoidu z kořene Scutellaria baicalensis, zhášet hydroxylové radikály, které byly generovány UV fotolýzou H2O2. Vychytávání hydroxylových radikálů bylo sledováno aromatickou hydroxylací kyseliny salicylové a hydroxylační produkty kyseliny salicylové, 2,3- a 2,5- dihydroxybenzové kyseliny, byly stanovovány pomocí HPLC. Bajkalin způsoboval snížení produkce těchto dihydroxybenzoových kyselin. Výsledky ukazují, že bajkalin zháší hydroxylové radikály generované UV fotolýzou H2O2. Hodnoty IC(50)byly hodnoceny. (cs)
Title
  • Hodnocení zhášecí aktivity bajkalinu vůči hydroxylovým radikálům pomocí HPLC (cs)
  • Evaluation of hydroxyl radical-scavenging activity of baicalin using HPLC method
  • Evaluation of hydroxyl radical-scavenging activity of baicalin using HPLC method (en)
skos:prefLabel
  • Hodnocení zhášecí aktivity bajkalinu vůči hydroxylovým radikálům pomocí HPLC (cs)
  • Evaluation of hydroxyl radical-scavenging activity of baicalin using HPLC method
  • Evaluation of hydroxyl radical-scavenging activity of baicalin using HPLC method (en)
skos:notation
  • RIV/00216224:14110/00:00003563!RIV09-GA0-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA303/00/D062)
http://linked.open...iv/cisloPeriodika
  • 10(1)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 710641
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/00:00003563
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • baicalin; hydroxyl radical (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [EB15E1D63C7A]
http://linked.open...i/riv/nazevZdroje
  • Pharm.Pharmacol.Lett.2000
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 2000
http://linked.open...iv/tvurceVysledku
  • Táborská, Eva
  • Paulová, Hana
  • Slanina, Jiří
  • Bochořáková, Hana
issn
  • 0939-9488
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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