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  • Procainamide (PA) is an effective antiarrhythmic drug used in the treatment of a variety of atrial and ventricular arrhythmias. The monitoring of serum concentrations of PA and its active metabolite, N-acetylprocainamide (NAPA), is ordered by the wide intersubject variability in genetically determined N-acetyltransferase activity. A simple and precise high performance liquid chromatography method for the determination of PA and NAPA in serum, urine and perfused fluid is presented. N-Propionylprocainamide was used as an internal standard. This assay is suitable for both therapeutic monitoring purposes and assessment of procainamide pharmacokinetics following a single oral dose of the drug.
  • Procainamide (PA) is an effective antiarrhythmic drug used in the treatment of a variety of atrial and ventricular arrhythmias. The monitoring of serum concentrations of PA and its active metabolite, N-acetylprocainamide (NAPA), is ordered by the wide intersubject variability in genetically determined N-acetyltransferase activity. A simple and precise high performance liquid chromatography method for the determination of PA and NAPA in serum, urine and perfused fluid is presented. N-Propionylprocainamide was used as an internal standard. This assay is suitable for both therapeutic monitoring purposes and assessment of procainamide pharmacokinetics following a single oral dose of the drug. (en)
  • Procainamide (PA) is an effective antiarrhythmic drug used in the treatment of a variety of atrial and ventricular arrhythmias. The monitoring of serum concentrations of PA and its active metabolite, N-acetylprocainamide (NAPA), is ordered by the wide intersubject variability in genetically determined N-acetyltransferase activity. A simple and precise high performance liquid chromatography method for the determination of PA and NAPA in serum, urine and perfused fluid is presented. N-Propionylprocainamide was used as an internal standard. This assay is suitable for both therapeutic monitoring purposes and assessment of procainamide pharmacokinetics following a single oral dose of the drug. (cs)
Title
  • Analysis of procainamide and N-acetylprocainamide by HPLC
  • Analysis of procainamide and N-acetylprocainamide by HPLC (en)
  • Analysis of procainamide and N-acetylprocainamide by HPLC (cs)
skos:prefLabel
  • Analysis of procainamide and N-acetylprocainamide by HPLC
  • Analysis of procainamide and N-acetylprocainamide by HPLC (en)
  • Analysis of procainamide and N-acetylprocainamide by HPLC (cs)
skos:notation
  • RIV/00216224:14110/00:00002347!RIV09-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 141100001)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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  • 704459
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/00:00002347
http://linked.open...riv/jazykVysledku
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  • procainamide - HPLC (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [129778D70C19]
http://linked.open...v/mistoKonaniAkce
  • 17.-19. září 2000 Pardubice
http://linked.open...i/riv/mistoVydani
  • Pardubice
http://linked.open...i/riv/nazevZdroje
  • FONS 2000. Sympozium klinické biochemie.
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Tomandl, Josef
  • Tallová, Jaroslava
  • McCaskey Hadašová, Eva
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
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  • STAPRO s.r.o.
https://schema.org/isbn
  • 80-238-5717-7
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  • 14110
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