About: Degradable Mg-Y-Nd-Mn alloys modified by Sc and Zn

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.4149/km_2012_5_351
Description	Magnesium alloys have been recently recognized as a biodegradable material for bone substitute application. Degradation rates of Mg alloys in the physiological environment, mechanical properties and cytocompatibility are interesting research topics up to now as their combination limits most clinical applications. At least the first two properties are in a direct connection with structure and microstructure of proposed materials. Two variants of the commercial WE-type alloy (Mg-Y-Nd-Zr) modified by Mn addition and Zr absence and alloyed with either Sc or Zn were studied in the as cast as well as in the T5 condition in this work. Yield tensile stress and ultimate tensile stress values at room temperature for both alloys studied after the T5 temper are comparable with those in the T6 treated commercial WE43 alloy. Hardening is caused by precipitation of prismatic plates non-uniformly distributed in matrices of both alloys. Ductility of both alloys regardless the treatment increases essentially compared to the WE43 alloy. Thin coherent hexagonal plates containing Zn and Y in a high number density and with a very high aspect ratio developed parallel to matrix basal planes during the T5 temper in the as cast Mg-Y-Nd-Zn-Mn alloy. The extracts of the studied alloys in EMEM prepared according to the ISO 10993-5 are cytotoxic for human osteosarcoma MG63 cells. The worst result was obtained for the T5 treated Mg-Y-Nd-Zn-Mn alloy and can be ascribed to the enhanced corrosion connected with the observed microstructure. The viability of Mg63 cells improves considerably in the ten times diluted extract, which is more realistic for a comparison with in vivo testing due to dynamic effects. Magnesium alloys have been recently recognized as a biodegradable material for bone substitute application. Degradation rates of Mg alloys in the physiological environment, mechanical properties and cytocompatibility are interesting research topics up to now as their combination limits most clinical applications. At least the first two properties are in a direct connection with structure and microstructure of proposed materials. Two variants of the commercial WE-type alloy (Mg-Y-Nd-Zr) modified by Mn addition and Zr absence and alloyed with either Sc or Zn were studied in the as cast as well as in the T5 condition in this work. Yield tensile stress and ultimate tensile stress values at room temperature for both alloys studied after the T5 temper are comparable with those in the T6 treated commercial WE43 alloy. Hardening is caused by precipitation of prismatic plates non-uniformly distributed in matrices of both alloys. Ductility of both alloys regardless the treatment increases essentially compared to the WE43 alloy. Thin coherent hexagonal plates containing Zn and Y in a high number density and with a very high aspect ratio developed parallel to matrix basal planes during the T5 temper in the as cast Mg-Y-Nd-Zn-Mn alloy. The extracts of the studied alloys in EMEM prepared according to the ISO 10993-5 are cytotoxic for human osteosarcoma MG63 cells. The worst result was obtained for the T5 treated Mg-Y-Nd-Zn-Mn alloy and can be ascribed to the enhanced corrosion connected with the observed microstructure. The viability of Mg63 cells improves considerably in the ten times diluted extract, which is more realistic for a comparison with in vivo testing due to dynamic effects. (en)
Title	Degradable Mg-Y-Nd-Mn alloys modified by Sc and Zn Degradable Mg-Y-Nd-Mn alloys modified by Sc and Zn (en)
skos:prefLabel	Degradable Mg-Y-Nd-Mn alloys modified by Sc and Zn Degradable Mg-Y-Nd-Mn alloys modified by Sc and Zn (en)
skos:notation	RIV/00216208:11320/12:10128728!RIV13-GA0-11320___
http://linked.open...avai/predkladatel	Matematicko-fyzikální fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA106/09/0407)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Stulíková, Ivana Smola, Bohumil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Matematicko-fyzikální fakulta
http://linked.open...dnocenehoVysledku	129885
http://linked.open...ai/riv/idVysledku	RIV/00216208:11320/12:10128728
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytocompatibility; corrosion; mechanical properties; degradable Mg alloys (en)
http://linked.open.../riv/klicoveSlovo	corrosion cytocompatibility mechanical properties degradable Mg alloys
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[FD86BC37F47F]
http://linked.open...i/riv/nazevZdroje	Kovove Materialy
http://linked.open...in/vavai/riv/obor	BM
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Basic investigation of Mg alloys for degradable implants
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	50
http://linked.open...iv/tvurceVysledku	Hnilica, František Joska, Luděk Smola, Bohumil Stulíková, Ivana Březina, Vítězslav
http://linked.open...ain/vavai/riv/wos	000313460200008
issn	0023-432X
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.4149/km_2012_5_351
http://localhost/t...ganizacniJednotka	11320
is http://linked.open...avai/riv/vysledek of	Degradable Mg-Y-Nd-Mn alloys modified by Sc and Zn

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