About: Functional Energetic Landscape in the Allosteric Regulation of Muscle Pyruvate Kinase. 2. Fluorescence Study

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About: Functional Energetic Landscape in the Allosteric Regulation of Muscle Pyruvate Kinase. 2. Fluorescence Study Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Four novel insights were uncovered. (1) ADP exhibits a dual property. Depending on the temperature, ADP can regulate RMPK activity by switching the enzyme to either the R or T state. (2) The assumption that ligand binding to RMPK is state-dependent is only correct for PEP but not Phe and ADP. (3) The effect of pH on the regulatory behavior of RMPK is partly due to the complex pattern of proton release or absorption linked to the multiple linked equilibria which govern the activity of the enzyme. (4) The R {-} T equilibrium is accompanied by a significant Delta C-p, rendering RMPK most sensitive to temperature under physiological conditions. Four novel insights were uncovered. (1) ADP exhibits a dual property. Depending on the temperature, ADP can regulate RMPK activity by switching the enzyme to either the R or T state. (2) The assumption that ligand binding to RMPK is state-dependent is only correct for PEP but not Phe and ADP. (3) The effect of pH on the regulatory behavior of RMPK is partly due to the complex pattern of proton release or absorption linked to the multiple linked equilibria which govern the activity of the enzyme. (4) The R {-} T equilibrium is accompanied by a significant Delta C-p, rendering RMPK most sensitive to temperature under physiological conditions. (en)
Title	Functional Energetic Landscape in the Allosteric Regulation of Muscle Pyruvate Kinase. 2. Fluorescence Study Functional Energetic Landscape in the Allosteric Regulation of Muscle Pyruvate Kinase. 2. Fluorescence Study (en)
skos:prefLabel	Functional Energetic Landscape in the Allosteric Regulation of Muscle Pyruvate Kinase. 2. Fluorescence Study Functional Energetic Landscape in the Allosteric Regulation of Muscle Pyruvate Kinase. 2. Fluorescence Study (en)
skos:notation	RIV/00216208:11320/09:00207044!RIV10-MSM-11320___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620835)
http://linked.open...iv/cisloPeriodika	40
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Heřman, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Matematicko-fyzikální fakulta
http://linked.open...dnocenehoVysledku	315709
http://linked.open...ai/riv/idVysledku	RIV/00216208:11320/09:00207044
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Functional; Energetic; Landscape; Allosteric; Regulation; Muscle; Pyruvate; Kinase; Fluorescence; Study (en)
http://linked.open.../riv/klicoveSlovo	Allosteric Energetic Functional Kinase Muscle Pyruvate Fluorescence Regulation Landscape Study
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[15936A139029]
http://linked.open...i/riv/nazevZdroje	Biochemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	40
http://linked.open...iv/tvurceVysledku	Heřman, Petr Lee, James C.
http://linked.open...ain/vavai/riv/wos	000270459100016
http://linked.open...n/vavai/riv/zamer	Fyzika molekulárních, makromolekulárních a biologických systémů
issn	0006-2960
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11320
is http://linked.open...avai/riv/vysledek of	Functional Energetic Landscape in the Allosteric Regulation of Muscle Pyruvate Kinase. 2. Fluorescence Study Functional Energetic Landscape in the Allosteric Regulation of Muscle Pyruvate Kinase. 2. Fluorescence Study Functional Energetic Landscape in the Allosteric Regulation of Muscle Pyruvate Kinase. 2. Fluorescence Study Functional Energetic Landscape in the Allosteric Regulation of Muscle Pyruvate Kinase. 2. Fluorescence Study

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