About: Chemoselective Synthesis of 4,5-Diarylpyrrolo[2,3-d]pyrimidines (6,7-Diaryl-7-deazapurines) by Consecutive Suzuki and Liebeskind-Srogl Cross-Couplings

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About: Chemoselective Synthesis of 4,5-Diarylpyrrolo[2,3-d]pyrimidines (6,7-Diaryl-7-deazapurines) by Consecutive Suzuki and Liebeskind-Srogl Cross-Couplings Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1002/ejoc.201402882
Description	A new chemoselective synthesis of pyrrolo[2,3-d]pyrimidines (7-deazapurines) bearing two different aryl groups at positions 4 and 5 was developed based on two orthogonal cross-couplings. Starting from 7-benzyl-protected 4-(phenylsulfanyl)-5-iodopyrrolo[2,3-d] pyrimidine, the Pd-catalyzed Suzuki coupling with arylboronic acids proceeded selectively at position 5, followed by the Pd-catalyzed Cu-mediated Liebeskind-Srogl coupling at position 4. A small library of 4,5-diaryl derivatives was prepared. A new chemoselective synthesis of pyrrolo[2,3-d]pyrimidines (7-deazapurines) bearing two different aryl groups at positions 4 and 5 was developed based on two orthogonal cross-couplings. Starting from 7-benzyl-protected 4-(phenylsulfanyl)-5-iodopyrrolo[2,3-d] pyrimidine, the Pd-catalyzed Suzuki coupling with arylboronic acids proceeded selectively at position 5, followed by the Pd-catalyzed Cu-mediated Liebeskind-Srogl coupling at position 4. A small library of 4,5-diaryl derivatives was prepared. (en)
Title	Chemoselective Synthesis of 4,5-Diarylpyrrolo[2,3-d]pyrimidines (6,7-Diaryl-7-deazapurines) by Consecutive Suzuki and Liebeskind-Srogl Cross-Couplings Chemoselective Synthesis of 4,5-Diarylpyrrolo[2,3-d]pyrimidines (6,7-Diaryl-7-deazapurines) by Consecutive Suzuki and Liebeskind-Srogl Cross-Couplings (en)
skos:prefLabel	Chemoselective Synthesis of 4,5-Diarylpyrrolo[2,3-d]pyrimidines (6,7-Diaryl-7-deazapurines) by Consecutive Suzuki and Liebeskind-Srogl Cross-Couplings Chemoselective Synthesis of 4,5-Diarylpyrrolo[2,3-d]pyrimidines (6,7-Diaryl-7-deazapurines) by Consecutive Suzuki and Liebeskind-Srogl Cross-Couplings (en)
skos:notation	RIV/00216208:11310/14:10283182!RIV15-MSM-11310___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP207/12/0205)
http://linked.open...iv/cisloPeriodika	32
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Krömer, Matouš Klečka, Martin Hocek, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	7118
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/14:10283182
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nitrogen heterocycles; palladium; cross-coupling; chemoselectivity; synthetic methods (en)
http://linked.open.../riv/klicoveSlovo	cross-coupling palladium nitrogen heterocycles synthetic methods chemoselectivity
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[EC1296E6197F]
http://linked.open...i/riv/nazevZdroje	European Journal of Organic Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of novel methodologies of C-H activations of purines, deazapurines, pyrimidines and related heterocycles
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	neuveden
http://linked.open...iv/tvurceVysledku	Hocek, Michal Klepetářová, Blanka Slavětínská, Lenka Klečka, Martin Krömer, Matouš
http://linked.open...ain/vavai/riv/wos	000344624000017
issn	1434-193X
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/ejoc.201402882
http://localhost/t...ganizacniJednotka	11310

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