About: Bioconjugated Iron Oxide Nanocubes: Synthesis, Functionalization, and Vectorization     Goto   Sponge   NotDistinct   Permalink

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Description
  • A facile bottom-up approach for the synthesis of inorganic/organic bioconjugated nanoprobes based on iron oxide nanocubes as the core with a nanometric silica shell is demonstrated. Surface coating and functionalization protocols developed in this work offered good control over the shell thickness (840 nm) and enabled biovectorization of SiO2@Fe3O4 coreshell structures by covalent attachment of folic acid (FA) as a targeting unit for cellular uptake. The successful immobilization of folic acid was investigated both quantitatively (TGA, EA, XPS) and qualitatively (AT-IR, UVvis, zeta-potential). Additionally, the magnetic behavior of the nanocomposites was monitored after each functionalization step. Cell viability studies confirmed low cytotoxicity of FA@SiO2@Fe3O4 conjugates, which makes them promising nanoprobes for targeted internalization by cells and their imaging.
  • A facile bottom-up approach for the synthesis of inorganic/organic bioconjugated nanoprobes based on iron oxide nanocubes as the core with a nanometric silica shell is demonstrated. Surface coating and functionalization protocols developed in this work offered good control over the shell thickness (840 nm) and enabled biovectorization of SiO2@Fe3O4 coreshell structures by covalent attachment of folic acid (FA) as a targeting unit for cellular uptake. The successful immobilization of folic acid was investigated both quantitatively (TGA, EA, XPS) and qualitatively (AT-IR, UVvis, zeta-potential). Additionally, the magnetic behavior of the nanocomposites was monitored after each functionalization step. Cell viability studies confirmed low cytotoxicity of FA@SiO2@Fe3O4 conjugates, which makes them promising nanoprobes for targeted internalization by cells and their imaging. (en)
Title
  • Bioconjugated Iron Oxide Nanocubes: Synthesis, Functionalization, and Vectorization
  • Bioconjugated Iron Oxide Nanocubes: Synthesis, Functionalization, and Vectorization (en)
skos:prefLabel
  • Bioconjugated Iron Oxide Nanocubes: Synthesis, Functionalization, and Vectorization
  • Bioconjugated Iron Oxide Nanocubes: Synthesis, Functionalization, and Vectorization (en)
skos:notation
  • RIV/00216208:11310/14:10281900!RIV15-MSM-11310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 19
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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  • 5311
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11310/14:10281900
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  • cytotoxicity; folic acid; magnetic properties; core-shell particles; iron oxide-silica; bioconjugated nanoprobes (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [0BA9D3C91050]
http://linked.open...i/riv/nazevZdroje
  • ACS applied materials & interfaces
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 6
http://linked.open...iv/tvurceVysledku
  • Nižňanský, Daniel
  • Mathur, Sanjay
  • Arroub, Karim
  • Berger, Nadja
  • Holmes, Justin
  • Ilyas, Shaista
  • Rahme, Kamil
  • Valldor, Martin
  • Wortmann, Laura
http://linked.open...ain/vavai/riv/wos
  • 000343018200021
issn
  • 1944-8244
number of pages
http://bibframe.org/vocab/doi
  • 10.1021/am503068r
http://localhost/t...ganizacniJednotka
  • 11310
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