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| Description
| - Diethylenetriamine-N, N,N',N '',N ''-pentaacetic acid (DTPA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) scandium(III) complexes were investigated in the solution and solid state. Three Sc-45 NMR spectroscopic references suitable for aqueous solutions were suggested: 0.1m Sc(ClO4)3 in 1m aq. HClO4 (ΔSc = 0.0 ppm), 0.1M ScCl3 in 1M aq. HCl (ΔSc = 1.75 ppm) and 0.01M [Sc(ox)4](5-) (ox2- = oxalato) in 1M aq. K2C2O4 (ΔSc = 8.31 ppm). In solution, [Sc-(dtpa)](2-) complex (ΔSc = 83 ppm, Δnu = 770 Hz) has a rather symmetric ligand field unlike highly unsymmetrical donor atom arrangement in [Sc(dota)](-) anion (ΔSc = 100 ppm, Δnu = 4300 Hz). The solid-state structure of K-8[Sc-2(ox)7] BULLET OPERATOR 13H2O contains two [Sc(ox)3](3-) units bridged by twice %22side-on%22 coordinated oxalate anion with Sc3+ ion in a dodecahedral O-8 arrangement. Structures of [Sc(dtpa)](2-) and [Sc(dota)]- in [(Hguanidine)](2)[Sc(dtpa)] BULLET OPERATOR 3H2O and K[Sc(dota)][H6dota]-Cl-2 BULLET OPERATOR 4H2O, respectively, are analogous to those of trivalent lanthanide complexes with the same ligands. The [Sc(dota)]- unit exhibits twisted square-antiprismatic arrangement without an axial ligand (TSA' isomer) and [Sc(dota)](-) and (H6dota)(2+) units are bridged by a K+ cation. A surprisingly high value of the last DOTA dissociation constant (pK(a) = 12.9) was determined by potentiometry and confirmed by using NMR spectroscopy. Stability constants of scandium(III) complexes (log K-ScL 27.43 and 30.79 for DTPA and DOTA, respectively) were determined from potentiometric and Sc-45 NMR spectroscopic data. Both complexes are fully formed even below pH 2. Complexation of DOTA with the Sc3+ ion is much faster than with trivalent lanthanides. Proton-assisted decomplexation of the [Sc(dota)]- complex (tau(1/2) = 45 h; 1M aq. HCl, 25 oC) is much slower than that for [Ln(dota)]- complexes. Therefore, DOTA and its derivatives seem to be very suitable ligands for scandium radioisotopes.
- Diethylenetriamine-N, N,N',N '',N ''-pentaacetic acid (DTPA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) scandium(III) complexes were investigated in the solution and solid state. Three Sc-45 NMR spectroscopic references suitable for aqueous solutions were suggested: 0.1m Sc(ClO4)3 in 1m aq. HClO4 (ΔSc = 0.0 ppm), 0.1M ScCl3 in 1M aq. HCl (ΔSc = 1.75 ppm) and 0.01M [Sc(ox)4](5-) (ox2- = oxalato) in 1M aq. K2C2O4 (ΔSc = 8.31 ppm). In solution, [Sc-(dtpa)](2-) complex (ΔSc = 83 ppm, Δnu = 770 Hz) has a rather symmetric ligand field unlike highly unsymmetrical donor atom arrangement in [Sc(dota)](-) anion (ΔSc = 100 ppm, Δnu = 4300 Hz). The solid-state structure of K-8[Sc-2(ox)7] BULLET OPERATOR 13H2O contains two [Sc(ox)3](3-) units bridged by twice %22side-on%22 coordinated oxalate anion with Sc3+ ion in a dodecahedral O-8 arrangement. Structures of [Sc(dtpa)](2-) and [Sc(dota)]- in [(Hguanidine)](2)[Sc(dtpa)] BULLET OPERATOR 3H2O and K[Sc(dota)][H6dota]-Cl-2 BULLET OPERATOR 4H2O, respectively, are analogous to those of trivalent lanthanide complexes with the same ligands. The [Sc(dota)]- unit exhibits twisted square-antiprismatic arrangement without an axial ligand (TSA' isomer) and [Sc(dota)](-) and (H6dota)(2+) units are bridged by a K+ cation. A surprisingly high value of the last DOTA dissociation constant (pK(a) = 12.9) was determined by potentiometry and confirmed by using NMR spectroscopy. Stability constants of scandium(III) complexes (log K-ScL 27.43 and 30.79 for DTPA and DOTA, respectively) were determined from potentiometric and Sc-45 NMR spectroscopic data. Both complexes are fully formed even below pH 2. Complexation of DOTA with the Sc3+ ion is much faster than with trivalent lanthanides. Proton-assisted decomplexation of the [Sc(dota)]- complex (tau(1/2) = 45 h; 1M aq. HCl, 25 oC) is much slower than that for [Ln(dota)]- complexes. Therefore, DOTA and its derivatives seem to be very suitable ligands for scandium radioisotopes. (en)
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| Title
| - Thermodynamic and Kinetic Study of Scandium(III) Complexes of DTPA and DOTA: A Step Toward Scandium Radiopharmaceuticals
- Thermodynamic and Kinetic Study of Scandium(III) Complexes of DTPA and DOTA: A Step Toward Scandium Radiopharmaceuticals (en)
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| skos:prefLabel
| - Thermodynamic and Kinetic Study of Scandium(III) Complexes of DTPA and DOTA: A Step Toward Scandium Radiopharmaceuticals
- Thermodynamic and Kinetic Study of Scandium(III) Complexes of DTPA and DOTA: A Step Toward Scandium Radiopharmaceuticals (en)
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| skos:notation
| - RIV/00216208:11310/14:10272016!RIV15-MSM-11310___
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - I, P(GA13-08336S), P(LD13012), S
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11310/14:10272016
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - scandium; radiopharmaceuticals; radiochemistry; NMR spectroscopy; ligands (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Chemistry - A European Journal
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Hermann, Petr
- Kotek, Jan
- Kubíček, Vojtěch
- Plutnar, Jan
- Havlíčková, Jana
- Pniok, Miroslav
- Huclier-Markai, Sandrine
- Sabatie-Gogova, Andrea
|
| http://linked.open...ain/vavai/riv/wos
| |
| issn
| |
| number of pages
| |
| http://bibframe.org/vocab/doi
| |
| http://localhost/t...ganizacniJednotka
| |
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