About: Enantioselective potential of chiral stationary phases based on immobilized polysaccharides in reversed phase mode

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://ac.els-cdn.com/S0021967314009649/1-s2.0-S0021967314009649-main.pdf?_tid=a08e9c2c-a563-11e4-9b5e-00000aab0f02&acdnat=1422280984_678c9a6ddb67419a5eabff83ae8279b0
Description	Derivatized polysaccharide-based columns have high enantiodiscrimination potential mainly in normal phase separation mode. In this work chiral recognition ability of four immobilized polysaccharide-derived chiral stationary phases was evaluated under reversed phase conditions. A set of 30 chiral compounds, particularly drugs possessing various functional groups was used for testing. Baseline enantioseparation was achieved for 17 of them. In general, amylose-based chiral stationary phases showed higher enantio- selectivity than the cellulose-based ones, mainly for acidic and bifunctional compounds. The influence of the type and pH of the aqueous mobile phase constituents a well as the role of the organic modifier on the enantioselective separation ability of the stationary phases were also investigated and compared. Com- plementary separations were obtained on the amylose- and cellulose-based columns. The immobilized polysaccharide-based chiral stationary phases were shown to be useful tool for the enantioseparation of a broad spectrum of chiral analytes in reversed phase separation mode. Derivatized polysaccharide-based columns have high enantiodiscrimination potential mainly in normal phase separation mode. In this work chiral recognition ability of four immobilized polysaccharide-derived chiral stationary phases was evaluated under reversed phase conditions. A set of 30 chiral compounds, particularly drugs possessing various functional groups was used for testing. Baseline enantioseparation was achieved for 17 of them. In general, amylose-based chiral stationary phases showed higher enantio- selectivity than the cellulose-based ones, mainly for acidic and bifunctional compounds. The influence of the type and pH of the aqueous mobile phase constituents a well as the role of the organic modifier on the enantioselective separation ability of the stationary phases were also investigated and compared. Com- plementary separations were obtained on the amylose- and cellulose-based columns. The immobilized polysaccharide-based chiral stationary phases were shown to be useful tool for the enantioseparation of a broad spectrum of chiral analytes in reversed phase separation mode. (en)
Title	Enantioselective potential of chiral stationary phases based on immobilized polysaccharides in reversed phase mode Enantioselective potential of chiral stationary phases based on immobilized polysaccharides in reversed phase mode (en)
skos:prefLabel	Enantioselective potential of chiral stationary phases based on immobilized polysaccharides in reversed phase mode Enantioselective potential of chiral stationary phases based on immobilized polysaccharides in reversed phase mode (en)
skos:notation	RIV/00216208:11310/14:10218674!RIV15-MSM-11310___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GP14-19278P), P(LH11018)
http://linked.open...iv/cisloPeriodika	OCT 10
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Geryk, Radim Vozka, Jiří Tesařová, Eva Kalíková, Květa Plecitá, Denisa
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	14498
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/14:10218674
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Derivatized cellulose; Derivatized amylose; Enantioselectivity; stationary phases; Immobilized polysaccharide-based chiral; Reversed phase mode; Chiralseparation (en)
http://linked.open.../riv/klicoveSlovo	Chiralseparation Derivatized amylose Derivatized cellulose Immobilized polysaccharide-based chiral Reversed phase mode Enantioselectivity stationary phases
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[B8DC299C3835]
http://linked.open...i/riv/nazevZdroje	Journal of Chromatography A
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Cyclofructans and their derivatives as new chiral selectors for liquid chromatography and capillary electrophoresis Simultaneous dynamic complexation equilibria of analytes and buffer constituents with complex-forming agents in analytical separation systems
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	1363
http://linked.open...iv/tvurceVysledku	Kalíková, Květa Tesařová, Eva Vozka, Jiří Schmid, Martin G. Plecitá, Denisa Geryk, Radim
http://linked.open...ain/vavai/riv/wos	000343359100019
issn	0021-9673
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.chroma.2014.06.040
http://localhost/t...ganizacniJednotka	11310

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