About: Backbone resonance assignments of human cytosolic dNT-1 nucleotidase

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://link.springer.com/article/10.1007/s12104-013-9531-1
Description	We report the backbone 1H, 13C and 15N assignments of NMR resonances for the 47 kDa Cytosolic dNT-1 nucleotidase dimer. Cytosolic dNT-1 nucleotidase plays a key role in the homeostasis of pyrimidine deoxyribonucleotides in mammalian cells. The enzyme is responsible for the dephosphorylation of physiological substrates as well as nucleoside analogues that are used in antiviral and anticancer therapies, therefore selective inhibition of the dNT-1 nucleotidase activity may lead to an increase in efficacy of this type of therapeutic compounds. Here, we report the backbone H-1, C-13 and N-15 assignments for the 47 kDa dNT-1 dimer, which will be used for structural characterisation of dNT-1 complexes with small molecule inhibitors obtained through modification of pyrimidine nucleotide scaffolds or optimisation of successful binders obtained from the screening of fragment libraries. We report the backbone 1H, 13C and 15N assignments of NMR resonances for the 47 kDa Cytosolic dNT-1 nucleotidase dimer. Cytosolic dNT-1 nucleotidase plays a key role in the homeostasis of pyrimidine deoxyribonucleotides in mammalian cells. The enzyme is responsible for the dephosphorylation of physiological substrates as well as nucleoside analogues that are used in antiviral and anticancer therapies, therefore selective inhibition of the dNT-1 nucleotidase activity may lead to an increase in efficacy of this type of therapeutic compounds. Here, we report the backbone H-1, C-13 and N-15 assignments for the 47 kDa dNT-1 dimer, which will be used for structural characterisation of dNT-1 complexes with small molecule inhibitors obtained through modification of pyrimidine nucleotide scaffolds or optimisation of successful binders obtained from the screening of fragment libraries. (en)
Title	Backbone resonance assignments of human cytosolic dNT-1 nucleotidase Backbone resonance assignments of human cytosolic dNT-1 nucleotidase (en)
skos:prefLabel	Backbone resonance assignments of human cytosolic dNT-1 nucleotidase Backbone resonance assignments of human cytosolic dNT-1 nucleotidase (en)
skos:notation	RIV/00216208:11310/14:10196792!RIV15-MSM-11310___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GA203/09/0820), P(LK11205)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Tošner, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	4748
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/14:10196792
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pyrimidine nucleotides; dimer; perdeuterated protein; 5 '-nucleotidase; haloacid dehalogenase superfamily; NMR; backbone assignments (en)
http://linked.open.../riv/klicoveSlovo	NMR dimer 5 '-nucleotidase backbone assignments haloacid dehalogenase superfamily perdeuterated protein pyrimidine nucleotides
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[A2D96FD79640]
http://linked.open...i/riv/nazevZdroje	Biomolecular NMR Assignments
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomolecular NMR spectroscopy for rational drug design Structure based drug design of specific nucleotidases inhibitors, potentially pharmacologically important compounds.
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Brynda, Jiří Fábry, Milan Pachl, Petr Hnízda, Aleš Tošner, Zdeněk Veverka, Václav Skleničková, Radka
http://linked.open...ain/vavai/riv/wos	000342080900042
issn	1874-2718
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s12104-013-9531-1
http://localhost/t...ganizacniJednotka	11310

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