About: Synthesis and biological activity of nitrogen-containing derivatives of α-santonin

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ksu.kz/files/Vestnik_KSU/Chemistry_4_72_2013.pdf
Description	The reactions of eudesmanolide α-santonin with primary and secondary amines were investigated. It was shown that the reactions occured regioselectively at the carbonyl group of γ-lactone ring with formation of the products of aminolysis - hydroxyamides. Furthermore, it was found that the reaction of santonin with semicarbazide and phenylhydrazine flowed through carbonyl group of cross-conjugated cyclodienone to form condensation products and the reaction of santonin with hydroxylamine flowed to give tandem reactions products of Michael-type and condensation. It was revealed that synthetic nitrogen-containing derivatives of α-santonin had antibacterial and antioxidant activity. The reactions of eudesmanolide α-santonin with primary and secondary amines were investigated. It was shown that the reactions occured regioselectively at the carbonyl group of γ-lactone ring with formation of the products of aminolysis - hydroxyamides. Furthermore, it was found that the reaction of santonin with semicarbazide and phenylhydrazine flowed through carbonyl group of cross-conjugated cyclodienone to form condensation products and the reaction of santonin with hydroxylamine flowed to give tandem reactions products of Michael-type and condensation. It was revealed that synthetic nitrogen-containing derivatives of α-santonin had antibacterial and antioxidant activity. (en)
Title	Synthesis and biological activity of nitrogen-containing derivatives of α-santonin Synthesis and biological activity of nitrogen-containing derivatives of α-santonin (en)
skos:prefLabel	Synthesis and biological activity of nitrogen-containing derivatives of α-santonin Synthesis and biological activity of nitrogen-containing derivatives of α-santonin (en)
skos:notation	RIV/00216208:11310/13:10191489!RIV14-MSM-11310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	72
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Vojtíšek, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	109462
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/13:10191489
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	desmotropsantonin; tandem reaction; Michael reaction; santonin; cyclodienone; cross-conjugation; eudesmanolide; sesquiterpene lactone (en)
http://linked.open.../riv/klicoveSlovo	Michael reaction cross-conjugation cyclodienone desmotropsantonin eudesmanolide santonin sesquiterpene lactone tandem reaction
http://linked.open...odStatuVydavatele	KZ - Republika Kazachstán
http://linked.open...ontrolniKodProRIV	[7682752C3333]
http://linked.open...i/riv/nazevZdroje	Bulletin of Karaganda State University, Series chemistry
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Vojtíšek, Pavel Abeuova, S. B. Bakytzhan, G. Merkhatuly, N. Suleimbekova, Z. S.
issn	0142-0843
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	11310

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