About: Highly chemoselective cobalt-catalyzed biaryl coupling reactions

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1039/c2sc21667a
Description	A practical cobalt-catalyzed hetero-biaryl coupling reaction between aryl chlorides and arylmagnesium halides with unprecedented selectivity has been developed. The protocol utilizes 1 mol% of cheap Co(acac)(3) as pre-catalyst and effects clean reactions of deactivated chlorostyrenes with only 1.1 equiv. of the Grignard reagent under mild conditions (30 degrees C, 5-30 min). Highly chemoselective reactions were realized even in the presence of activated bromoarenes. The olefin substituent facilitates the activation of the C-Cl bond by coordination to the catalyst. Kinetic studies indicate the operation of an arylcobaltate(I) catalyst species. Catalyst formation during the induction period was studied in the presence of cobalt(III), (I), and (-I) pre-catalysts. A practical cobalt-catalyzed hetero-biaryl coupling reaction between aryl chlorides and arylmagnesium halides with unprecedented selectivity has been developed. The protocol utilizes 1 mol% of cheap Co(acac)(3) as pre-catalyst and effects clean reactions of deactivated chlorostyrenes with only 1.1 equiv. of the Grignard reagent under mild conditions (30 degrees C, 5-30 min). Highly chemoselective reactions were realized even in the presence of activated bromoarenes. The olefin substituent facilitates the activation of the C-Cl bond by coordination to the catalyst. Kinetic studies indicate the operation of an arylcobaltate(I) catalyst species. Catalyst formation during the induction period was studied in the presence of cobalt(III), (I), and (-I) pre-catalysts. (en)
Title	Highly chemoselective cobalt-catalyzed biaryl coupling reactions Highly chemoselective cobalt-catalyzed biaryl coupling reactions (en)
skos:prefLabel	Highly chemoselective cobalt-catalyzed biaryl coupling reactions Highly chemoselective cobalt-catalyzed biaryl coupling reactions (en)
skos:notation	RIV/00216208:11310/13:10133687!RIV14-MSM-11310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kotora, Martin Štěpánek, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	77402
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/13:10133687
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	dimerization; electrophiles; polymerization; chlorides; iron; complexes; p-chlorostyrene; styrene derivatives; alkyl-halides; aryl grignard-reagents (en)
http://linked.open.../riv/klicoveSlovo	complexes dimerization iron chlorides polymerization alkyl-halides aryl grignard-reagents electrophiles p-chlorostyrene styrene derivatives
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[0E128C423E27]
http://linked.open...i/riv/nazevZdroje	Chemical Science
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Kotora, Martin Štěpánek, Ondřej Guelak, Samet Malberg, Jennifer Rad, Babak Rezaei Wolf, Robert von Wangelin, Axel Jacobi
http://linked.open...ain/vavai/riv/wos	000312946500030
issn	2041-6520
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/c2sc21667a
http://localhost/t...ganizacniJednotka	11310

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