About: Efficient Iron Uptake via a Reductive Mechanism in Procyclic Trypanosoma brucei     Goto   Sponge   NotDistinct   Permalink

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Description
  • The bloodstream form of T. brucei acquires iron from transferrin via receptor-mediated endocytosis. However, it is unknown how procyclic forms that cannot bind transferrin acquire iron. In this study, we show that the procyclic form of T. brucei efficiently takes up iron from ferric complexes via a reductive mechanism and that iron obtained using this mechanism is transported to and used in the mitochondria. The affinity of the transport system is comparable to that of Saccharomyces cerevisiae, with an apparent Km of 0.85 μM.
  • The bloodstream form of T. brucei acquires iron from transferrin via receptor-mediated endocytosis. However, it is unknown how procyclic forms that cannot bind transferrin acquire iron. In this study, we show that the procyclic form of T. brucei efficiently takes up iron from ferric complexes via a reductive mechanism and that iron obtained using this mechanism is transported to and used in the mitochondria. The affinity of the transport system is comparable to that of Saccharomyces cerevisiae, with an apparent Km of 0.85 μM. (en)
Title
  • Efficient Iron Uptake via a Reductive Mechanism in Procyclic Trypanosoma brucei
  • Efficient Iron Uptake via a Reductive Mechanism in Procyclic Trypanosoma brucei (en)
skos:prefLabel
  • Efficient Iron Uptake via a Reductive Mechanism in Procyclic Trypanosoma brucei
  • Efficient Iron Uptake via a Reductive Mechanism in Procyclic Trypanosoma brucei (en)
skos:notation
  • RIV/00216208:11310/13:10124296!RIV14-MSM-11310___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(LC07032), S, Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 72077
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11310/13:10124296
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Iron; Trypanosoma brucei (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [D853BFD22FD1]
http://linked.open...i/riv/nazevZdroje
  • Journal of Parasitology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 99
http://linked.open...iv/tvurceVysledku
  • Mach, Jan
  • Tachezy, Jan
  • Šuťák, Róbert
http://linked.open...ain/vavai/riv/wos
  • 000322520700031
http://linked.open...n/vavai/riv/zamer
issn
  • 0022-3395
number of pages
http://bibframe.org/vocab/doi
  • 10.1645/GE-3237.1
http://localhost/t...ganizacniJednotka
  • 11310
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