About: Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: Trichomonas vaginalis is the most common non-viral human sexually transmitted pathogen and importantly, contributes to facilitating the spread of HIV. Yet very little is known about its surface and secreted proteins mediating interactions with, and permitting the invasion and colonisation of, the host mucosa. Initial annotations of T. vaginalis genome identified a plethora of candidate extracellular proteins. Results: Data mining of the T. vaginalis genome identified 911 BspA-like entries (TvBspA) sharing TpLRR-like leucine-rich repeats, which represent the largest gene family encoding potential extracellular proteins for the pathogen. A broad range of microorganisms encoding BspA-like proteins was identified and these are mainly known to live on mucosal surfaces, among these T. vaginalis is endowed with the largest gene family. Background: Trichomonas vaginalis is the most common non-viral human sexually transmitted pathogen and importantly, contributes to facilitating the spread of HIV. Yet very little is known about its surface and secreted proteins mediating interactions with, and permitting the invasion and colonisation of, the host mucosa. Initial annotations of T. vaginalis genome identified a plethora of candidate extracellular proteins. Results: Data mining of the T. vaginalis genome identified 911 BspA-like entries (TvBspA) sharing TpLRR-like leucine-rich repeats, which represent the largest gene family encoding potential extracellular proteins for the pathogen. A broad range of microorganisms encoding BspA-like proteins was identified and these are mainly known to live on mucosal surfaces, among these T. vaginalis is endowed with the largest gene family. (en)
Title	Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics (en)
skos:prefLabel	Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics (en)
skos:notation	RIV/00216208:11310/10:10080553!RIV11-MSM-11310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC07032), Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Šafaříková, Lucie Tachezy, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	293606
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/10:10080553
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	virulence factors; clostridium-difficile; molecular characterization; epithelial-cells; entamoeba-histolytica; tannerella-forsythia; amino-acid repeats; signal peptide prediction; combined transmembrane topology; Leucine-rich-repeat (en)
http://linked.open.../riv/klicoveSlovo	virulence factors molecular characterization entamoeba-histolytica Leucine-rich-repeat amino-acid repeats clostridium-difficile combined transmembrane topology signal peptide prediction tannerella-forsythia epithelial-cells
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2A8D3748F8A4]
http://linked.open...i/riv/nazevZdroje	BMC Genomics
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Functional Genetics
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Tachezy, Jan Tang, Petrus Šafaříková, Lucie Diaz, Nicia Fiori, Pier-Luigi Hirt, Robert P. Noel, Christophe J. Sicheritz-Ponten, Thomas
http://linked.open...ain/vavai/riv/wos	000275835100001
http://linked.open...n/vavai/riv/zamer	Signaling and cellular response mechanisms
issn	1471-2164
number of pages	26 (xsd:int)
http://localhost/t...ganizacniJednotka	11310
is http://linked.open...avai/riv/vysledek of	Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics

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