About: The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen     Goto   Sponge   NotDistinct   Permalink

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Description
  • Reductive activation of human carcinogen (aristolochic acid I) by human cytochromes P450 1A1 and 1A2 was shown. The resulting DNA adducts reproduce the patterns found in renal tissues from humans.
  • Reductive activation of human carcinogen (aristolochic acid I) by human cytochromes P450 1A1 and 1A2 was shown. The resulting DNA adducts reproduce the patterns found in renal tissues from humans. (en)
Title
  • The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen
  • The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen (en)
skos:prefLabel
  • The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen
  • The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen (en)
skos:notation
  • RIV/00216208:11310/05:00008044!RIV10-MSM-11310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 113100001)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 513797
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11310/05:00008044
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • aristolochic acid; carcinogen; urothelial cancer; cytochromes P450 1A1 and 1A2; reductive activation; DNA adduct; computer modeling; docking (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • IE - Irsko
http://linked.open...ontrolniKodProRIV
  • [68CFE00FFB71]
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  • CANCER LETTERS
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 229
http://linked.open...iv/tvurceVysledku
  • Frei, Eva
  • Hodek, Petr
  • Hudeček, Jiří
  • Sopko, Bruno
  • Stiborová, Marie
  • Schmeiser, H H.
http://linked.open...ain/vavai/riv/wos
  • 000233328900004
http://linked.open...n/vavai/riv/zamer
issn
  • 0304-3835
number of pages
http://localhost/t...ganizacniJednotka
  • 11310
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