About: Hydrophilic interaction chromatography of polar and ionizable compounds by UHPLC

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0165993614001976
Description	In recent years, the popularity of hydrophilic interaction chromatography (HILIC) in the analysis of small polar and ionizable molecules increased substantially. A large number of new stationary phases with sub-2-micro m and superficially porous particles were developed and used in various applications, including pharmaceuticals, metabolites, biomarkers, amino acids and peptides. Applications of HILIC in ultra-high performance liquid chromatography (UHPLC) mode constitute only about 10% of all current HILIC applications. This review presents an overview of UHPLC in HILIC mode, including the importance of the final sample diluent, a discussion on available stationary phases and approaches to detection, and a comparison of performance with other chromatographic modes. In recent years, the popularity of hydrophilic interaction chromatography (HILIC) in the analysis of small polar and ionizable molecules increased substantially. A large number of new stationary phases with sub-2-micro m and superficially porous particles were developed and used in various applications, including pharmaceuticals, metabolites, biomarkers, amino acids and peptides. Applications of HILIC in ultra-high performance liquid chromatography (UHPLC) mode constitute only about 10% of all current HILIC applications. This review presents an overview of UHPLC in HILIC mode, including the importance of the final sample diluent, a discussion on available stationary phases and approaches to detection, and a comparison of performance with other chromatographic modes. (en)
Title	Hydrophilic interaction chromatography of polar and ionizable compounds by UHPLC Hydrophilic interaction chromatography of polar and ionizable compounds by UHPLC (en)
skos:prefLabel	Hydrophilic interaction chromatography of polar and ionizable compounds by UHPLC Hydrophilic interaction chromatography of polar and ionizable compounds by UHPLC (en)
skos:notation	RIV/00216208:11160/14:10282206!RIV15-MSM-11160___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(EE2.3.30.0022)
http://linked.open...iv/cisloPeriodika	December
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Nováková, Lucie Vlčková, Hana Havlíková, Lucie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	20117
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/14:10282206
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	UHPLC; Ultra-high performance liquid chromatography; Stationary phase; Sensitivity; Selectivity; Mobile phase; Matrix effect; Hydrophilic interaction chromatography; HILIC; Dissolution solvent (en)
http://linked.open.../riv/klicoveSlovo	Matrix effect Sensitivity UHPLC Selectivity Stationary phase Mobile phase HILIC Hydrophilic interaction chromatography Dissolution solvent Ultra-high performance liquid chromatography
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[4CD04F41EACC]
http://linked.open...i/riv/nazevZdroje	TrAC - Trends in Analytical Chemistry
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Support of establishment, development, and mobility of quality research teams at the Charles University
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	63
http://linked.open...iv/tvurceVysledku	Nováková, Lucie Vlčková, Hana Havlíková, Lucie
http://linked.open...ain/vavai/riv/wos	000347274400016
issn	0165-9936
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.trac.2014.08.004
http://localhost/t...ganizacniJednotka	11160

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