About: Cyclic Swelling as a Phenomenon Inherent to Biodagradable Polyesters

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About: Cyclic Swelling as a Phenomenon Inherent to Biodagradable Polyesters Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1002/jps.24146/full
Description	The aim of this study is to evaluate and describe the phenomenon and mechanism of the spontaneous cyclic swelling and deswelling of linear and branched aliphatic polyesters in the aqueous medium. The fluctuation of gel volume in one or several cycles as an inherent property of biodegradable and bioerodible materials has not yet been described. We have observed the process at linear and branched polyesters of aliphatic -hydroxy acids. The period of duration of cycles was in order of hours to days, as influenced by the size of the bodies ranging from 25 to 1000 mg, the temperature in the range of 7 degrees C-42 degrees C, ionic strength, and pH value. The results demonstrated that swelling is accompanied by hydrolysis of ester bonds with the development of small water-soluble osmotically active molecules. After reaching a higher degree of swelling, the obstruction effect of the gel decreases and the diffusion of soluble degradation products from the body to the environment prevails. A decrease in osmotic pressure inside the body and a decrease in the hydrophilic character of the gel matrix result in deswelling by a collapse of the structure, probably due to hydrophobic interactions of nonpolar polyester chains. The aim of this study is to evaluate and describe the phenomenon and mechanism of the spontaneous cyclic swelling and deswelling of linear and branched aliphatic polyesters in the aqueous medium. The fluctuation of gel volume in one or several cycles as an inherent property of biodegradable and bioerodible materials has not yet been described. We have observed the process at linear and branched polyesters of aliphatic -hydroxy acids. The period of duration of cycles was in order of hours to days, as influenced by the size of the bodies ranging from 25 to 1000 mg, the temperature in the range of 7 degrees C-42 degrees C, ionic strength, and pH value. The results demonstrated that swelling is accompanied by hydrolysis of ester bonds with the development of small water-soluble osmotically active molecules. After reaching a higher degree of swelling, the obstruction effect of the gel decreases and the diffusion of soluble degradation products from the body to the environment prevails. A decrease in osmotic pressure inside the body and a decrease in the hydrophilic character of the gel matrix result in deswelling by a collapse of the structure, probably due to hydrophobic interactions of nonpolar polyester chains. (en)
Title	Cyclic Swelling as a Phenomenon Inherent to Biodagradable Polyesters Cyclic Swelling as a Phenomenon Inherent to Biodagradable Polyesters (en)
skos:prefLabel	Cyclic Swelling as a Phenomenon Inherent to Biodagradable Polyesters Cyclic Swelling as a Phenomenon Inherent to Biodagradable Polyesters (en)
skos:notation	RIV/00216208:11160/14:10281994!RIV15-MSM-11160___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Šnejdrová, Eva Dittrich, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	9508
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/14:10281994
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	glass transition; diffusion; chemical stability; gels; poly(lactic/glycolic) acid; biodegradable polymers (en)
http://linked.open.../riv/klicoveSlovo	glass transition chemical stability biodegradable polymers diffusion gels poly(lactic/glycolic) acid
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[861E198A0953]
http://linked.open...i/riv/nazevZdroje	Journal of Pharmaceutical Sciences
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	103
http://linked.open...iv/tvurceVysledku	Dittrich, Milan Šnejdrová, Eva
http://linked.open...ain/vavai/riv/wos	000344145200022
issn	0022-3549
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/jps.24146
http://localhost/t...ganizacniJednotka	11160

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