About: Evaluation of the antioxidant activity of several naturally occurring coumarins and their synthesized analogues by %22ferric reducing antioxidant power%22 assay

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About: Evaluation of the antioxidant activity of several naturally occurring coumarins and their synthesized analogues by %22ferric reducing antioxidant power%22 assay Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://informahealthcare.com/doi/full/10.3109/14756366.2012.753589
Description	Coumarins have attracted intense interest in recent years because of their diverse pharmacological properties. According to our continuing investigations of biological effects of several coumarins, the structure-antioxidant activity relationships (SARs) of six naturally occurring coumarins and their 16 synthesized analogues were established. For this purpose, the very reliable colorimetric assay (ferric reducing antioxidant power) modified to be used in 96-well microplates was used. This approach, which determines the reducing capacity of tested compounds directly, has previously been used for the determination of SARs of flavonoids, but has not been used for SAR determination of coumarins. It is known that the biological properties and consequently, therapeutic application of simple coumarins depends upon the pattern of substitution. It was established that 7,8-dihydroxy- and 6,7-dihydroxy-4-methylcoumarins have shown excellent ferric-reducing properties. Coumarins have attracted intense interest in recent years because of their diverse pharmacological properties. According to our continuing investigations of biological effects of several coumarins, the structure-antioxidant activity relationships (SARs) of six naturally occurring coumarins and their 16 synthesized analogues were established. For this purpose, the very reliable colorimetric assay (ferric reducing antioxidant power) modified to be used in 96-well microplates was used. This approach, which determines the reducing capacity of tested compounds directly, has previously been used for the determination of SARs of flavonoids, but has not been used for SAR determination of coumarins. It is known that the biological properties and consequently, therapeutic application of simple coumarins depends upon the pattern of substitution. It was established that 7,8-dihydroxy- and 6,7-dihydroxy-4-methylcoumarins have shown excellent ferric-reducing properties. (en)
Title	Evaluation of the antioxidant activity of several naturally occurring coumarins and their synthesized analogues by %22ferric reducing antioxidant power%22 assay Evaluation of the antioxidant activity of several naturally occurring coumarins and their synthesized analogues by %22ferric reducing antioxidant power%22 assay (en)
skos:prefLabel	Evaluation of the antioxidant activity of several naturally occurring coumarins and their synthesized analogues by %22ferric reducing antioxidant power%22 assay Evaluation of the antioxidant activity of several naturally occurring coumarins and their synthesized analogues by %22ferric reducing antioxidant power%22 assay (en)
skos:notation	RIV/00216208:11160/14:10281952!RIV15-MSM-11160___
http://linked.open...avai/riv/aktivita	I P S V
http://linked.open...avai/riv/aktivity	I, P(EE2.3.20.0235), S, V
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Cahlíková, Lucie Macáková, Kateřina Opletal, Lubomír Kolečkář, Vít Jahodář, Luděk Řeháková, Zuzana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	15462
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/14:10281952
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	structure-activity relationship; ferric reducing antioxidant power; coumarins; Antioxidant (en)
http://linked.open.../riv/klicoveSlovo	Antioxidant coumarins structure-activity relationship ferric reducing antioxidant power
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[4E38A89F140B]
http://linked.open...i/riv/nazevZdroje	Journal of Enzyme Inhibition and Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Establishment of Research Team Focused on Experimental and Applied Biopharmacy
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Kuča, Kamil Cahlíková, Lucie Jun, Daniel Macáková, Kateřina Opletal, Lubomír Jahodář, Luděk Řeháková, Zuzana Kolečkář, Vít
http://linked.open...ain/vavai/riv/wos	000330850300009
issn	1475-6366
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.3109/14756366.2012.753589
http://localhost/t...ganizacniJednotka	11160

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