About: The Chemistry and Biology of 6-Hydroxyceramide, the Youngest Member of the Human Sphingolipid Family

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The Chemistry and Biology of 6-Hydroxyceramide, the Youngest Member of the Human Sphingolipid Family Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1002/cbic.201402153/full
Description	Sphingolipids are crucial for the life of the cell. In land-dwelling mammals, they are equally important outside the cell-in the extracellular space of the skin barrier-because they prevent loss of water. Although a large body of research has elucidated many of the functions of sphingolipids, their extensive structural diversity remains intriguing. A new class of sphingolipids based on 6-hydroxylated sphingosine has recently been identified in human skin. Abnormal levels of these 6-hydroxylated ceramides have repeatedly been observed in atopic dermatitis; however, neither the biosynthesis nor the roles of these unique ceramide subclasses have been established in the human body. In this Minireview, we summarize the current knowledge of 6-hydroxyceramides, including their discovery, structure, stereochemistry, occurrence in healthy and diseased human epidermis, and synthetic approaches to 6-hydroxysphingosine and related ceramides. Sphingolipids are crucial for the life of the cell. In land-dwelling mammals, they are equally important outside the cell-in the extracellular space of the skin barrier-because they prevent loss of water. Although a large body of research has elucidated many of the functions of sphingolipids, their extensive structural diversity remains intriguing. A new class of sphingolipids based on 6-hydroxylated sphingosine has recently been identified in human skin. Abnormal levels of these 6-hydroxylated ceramides have repeatedly been observed in atopic dermatitis; however, neither the biosynthesis nor the roles of these unique ceramide subclasses have been established in the human body. In this Minireview, we summarize the current knowledge of 6-hydroxyceramides, including their discovery, structure, stereochemistry, occurrence in healthy and diseased human epidermis, and synthetic approaches to 6-hydroxysphingosine and related ceramides. (en)
Title	The Chemistry and Biology of 6-Hydroxyceramide, the Youngest Member of the Human Sphingolipid Family The Chemistry and Biology of 6-Hydroxyceramide, the Youngest Member of the Human Sphingolipid Family (en)
skos:prefLabel	The Chemistry and Biology of 6-Hydroxyceramide, the Youngest Member of the Human Sphingolipid Family The Chemistry and Biology of 6-Hydroxyceramide, the Youngest Member of the Human Sphingolipid Family (en)
skos:notation	RIV/00216208:11160/14:10281636!RIV15-MSM-11160___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GA13-23891S), S
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Vávrová, Kateřina Roh, Jaroslav Kováčik, Andrej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	7110
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/14:10281636
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	sphingolipids; skin; membranes; lipids; ceramides (en)
http://linked.open.../riv/klicoveSlovo	ceramides sphingolipids membranes skin lipids
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[F71EA6976118]
http://linked.open...i/riv/nazevZdroje	ChemBioChem
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Vávrová, Kateřina Roh, Jaroslav Kováčik, Andrej
http://linked.open...ain/vavai/riv/wos	000339502900002
issn	1439-4227
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/cbic.201402153
http://localhost/t...ganizacniJednotka	11160

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software