About: Metabolic pathways of anthelmintic drug monepantel in sheep and in its parasite (Haemonchus contortus)

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About: Metabolic pathways of anthelmintic drug monepantel in sheep and in its parasite (Haemonchus contortus) Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1002/dta.1630/full
Description	The aim of our study was to find out metabolic pathways of MOP in sheep in vivo and in its parasite Haemonchus contortus ex vivo. MOP biotransformation in two H. contortus strains with different sensitivity to anthelmintics was also compared. Ultrahigh-performance liquid chromatography with tandem mass spectrometry (UHPLC/MS/MS) technique is used for the identification of MOP metabolites in ovine urine, faeces and in nematodes. MOP biotransformation study in sheep in vivo led to the identification of 13 MOP metabolites, 7 of them have not been described previously in in vitro study. The study of MOP biotransformation in H. contorus ex vivo reveals 4 MOP metabolites. The nitrile hydrolysis as a new biotransformation pathway in helminths ex vivo is reported here for the first time. The aim of our study was to find out metabolic pathways of MOP in sheep in vivo and in its parasite Haemonchus contortus ex vivo. MOP biotransformation in two H. contortus strains with different sensitivity to anthelmintics was also compared. Ultrahigh-performance liquid chromatography with tandem mass spectrometry (UHPLC/MS/MS) technique is used for the identification of MOP metabolites in ovine urine, faeces and in nematodes. MOP biotransformation study in sheep in vivo led to the identification of 13 MOP metabolites, 7 of them have not been described previously in in vitro study. The study of MOP biotransformation in H. contorus ex vivo reveals 4 MOP metabolites. The nitrile hydrolysis as a new biotransformation pathway in helminths ex vivo is reported here for the first time. (en)
Title	Metabolic pathways of anthelmintic drug monepantel in sheep and in its parasite (Haemonchus contortus) Metabolic pathways of anthelmintic drug monepantel in sheep and in its parasite (Haemonchus contortus) (en)
skos:prefLabel	Metabolic pathways of anthelmintic drug monepantel in sheep and in its parasite (Haemonchus contortus) Metabolic pathways of anthelmintic drug monepantel in sheep and in its parasite (Haemonchus contortus) (en)
skos:notation	RIV/00216208:11160/14:10281582!RIV15-MSM-11160___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GAP502/10/0217), S
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Skálová, Lenka Lamka, Jiří Szotáková, Barbora Vokřál, Ivan Stuchlíková, Lucie Valát, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	28526
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/14:10281582
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	biotransformation; nematodes; mass spectrometry; amino-acetonitrile derivatives; UHPLC-MS (en)
http://linked.open.../riv/klicoveSlovo	amino-acetonitrile derivatives mass spectrometry nematodes biotransformation UHPLC-MS
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[28C399A8D05A]
http://linked.open...i/riv/nazevZdroje	Drug Testing and Analysis
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Drug-resistance development in helminths - possible mechanisms and defense
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Holčapek, Michal Lamka, Jiří Skálová, Lenka Jirásko, Robert Szotáková, Barbora Vokřál, Ivan Stuchlíková, Lucie Valát, Martin
http://linked.open...ain/vavai/riv/wos	000343814800011
issn	1942-7603
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/dta.1630
http://localhost/t...ganizacniJednotka	11160

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