About: Antibacterial Activity of Salicylanilide 4-(Trifluoromethyl)benzoates

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About: Antibacterial Activity of Salicylanilide 4-(Trifluoromethyl)benzoates Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.mdpi.com/1420-3049/18/4/3674/pdf
Description	The development of novel antimicrobial agents represents a timely research topic. Eighteen salicylanilide 4-(trifluoromethyl)benzoates were evaluated against Mycobacterium tuberculosis, M. avium and M. kansasii, eight bacterial strains including methicillin-resistant Staphylococcus aureus (MRSA) and for the inhibition of mycobacterial isocitrate lyase. Some compounds were further screened against drug-resistant M. tuberculosis and for their cytotoxicity. Minimum inhibitory concentrations (MICs) for all mycobacterial strains were within 0.5-32 mu mol/L, with 4-chloro-2-[4-(trifluoromethyl)phenylcarbamoyl] phenyl 4-(trifluoromethyl) benzoate superiority. Grampositive bacteria including MRSA were inhibited with MICs }= 0.49 mu mol/L, while Gram-negative ones were much less susceptible. Salicylanilide 4-(trifluoromethyl) benzoates showed significant antibacterial properties, for many strains being comparable to standard drugs (isoniazid, benzylpenicillin) with no cross-resistance. All esters showed mild inhibition of mycobacterial isocitrate lyase and four compounds were comparable to 3-nitropropionic acid without a direct correlation between in vitro MICs and enzyme inhibition. The development of novel antimicrobial agents represents a timely research topic. Eighteen salicylanilide 4-(trifluoromethyl)benzoates were evaluated against Mycobacterium tuberculosis, M. avium and M. kansasii, eight bacterial strains including methicillin-resistant Staphylococcus aureus (MRSA) and for the inhibition of mycobacterial isocitrate lyase. Some compounds were further screened against drug-resistant M. tuberculosis and for their cytotoxicity. Minimum inhibitory concentrations (MICs) for all mycobacterial strains were within 0.5-32 mu mol/L, with 4-chloro-2-[4-(trifluoromethyl)phenylcarbamoyl] phenyl 4-(trifluoromethyl) benzoate superiority. Grampositive bacteria including MRSA were inhibited with MICs }= 0.49 mu mol/L, while Gram-negative ones were much less susceptible. Salicylanilide 4-(trifluoromethyl) benzoates showed significant antibacterial properties, for many strains being comparable to standard drugs (isoniazid, benzylpenicillin) with no cross-resistance. All esters showed mild inhibition of mycobacterial isocitrate lyase and four compounds were comparable to 3-nitropropionic acid without a direct correlation between in vitro MICs and enzyme inhibition. (en)
Title	Antibacterial Activity of Salicylanilide 4-(Trifluoromethyl)benzoates Antibacterial Activity of Salicylanilide 4-(Trifluoromethyl)benzoates (en)
skos:prefLabel	Antibacterial Activity of Salicylanilide 4-(Trifluoromethyl)benzoates Antibacterial Activity of Salicylanilide 4-(Trifluoromethyl)benzoates (en)
skos:notation	RIV/00216208:11160/13:10145614!RIV14-MZ0-11160___
http://linked.open...avai/predkladatel	Farmaceutická fakulta v Hradci Králové
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(EE2.3.30.0022), P(NT13346)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Krátký, Martin Novotná, Eva Mandíková, Jana Trejtnar, František Vinšová, Jarmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	61357
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/13:10145614
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	4-(trifluoromethyl)benzoic acid ester; salicylanilide ester; multidrug-resistant tuberculosis; isocitrate lyase inhibitor; cytotoxicity; antimycobacterial activity; antibacterial activity (en)
http://linked.open.../riv/klicoveSlovo	antibacterial activity cytotoxicity salicylanilide ester isocitrate lyase inhibitor 4-(trifluoromethyl)benzoic acid ester multidrug-resistant tuberculosis antimycobacterial activity
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[A42CB2E4C190]
http://linked.open...i/riv/nazevZdroje	Molecules
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Design and enzyme targeting of antibacterial active compounds against multidrug resistant strains Support of establishment, development, and mobility of quality research teams at the Charles University
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Krátký, Martin Novotná, Eva Vinšová, Jarmila Mandíková, Jana Stolaříková, Jiřina Trejtnar, František
http://linked.open...ain/vavai/riv/wos	000318020100002
issn	1420-3049
number of pages	15 (xsd:int)
http://bibframe.org/vocab/doi	10.3390/molecules18043674
http://localhost/t...ganizacniJednotka	11160

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