About: High active potential antimycobacterial agents against Mycobacterium avium

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.prolekare.cz/ceska-slovenska-farmacie-clanek/vysoce-ucinne-potencialni-antimykobakterialni-latky-proti-em-mycobacterium-avium-em-38561
Description	Derivatives of 3-phenyl-2H-1,3-benzoxazme-2,4(3H)- -dione are active against Mycobacterium avium when substituted in position 7 with a methyl. One or two carbonyl groups have to be replaced with a thioxo group. High active derivatives are the compounds without substitution on the phenyl, or those substituted on the phenyl in position 3 or 4 with chlorine, bromine or a methyl. The substitution in position 3 and 4 with two atoms of chlorine lowers the activity. The compounds are active against INH resistant strains. We synthesized other 44 derivatives with a similar structure of the compounds as in the paper but substituted in position 7 with other substituents (chlorine, bromine methoxy). The activity against M. avium was poor. It can be concluded that a new group of compounds with an excellent activity against M. avium has been found. Derivatives of 3-phenyl-2H-1,3-benzoxazme-2,4(3H)- -dione are active against Mycobacterium avium when substituted in position 7 with a methyl. One or two carbonyl groups have to be replaced with a thioxo group. High active derivatives are the compounds without substitution on the phenyl, or those substituted on the phenyl in position 3 or 4 with chlorine, bromine or a methyl. The substitution in position 3 and 4 with two atoms of chlorine lowers the activity. The compounds are active against INH resistant strains. We synthesized other 44 derivatives with a similar structure of the compounds as in the paper but substituted in position 7 with other substituents (chlorine, bromine methoxy). The activity against M. avium was poor. It can be concluded that a new group of compounds with an excellent activity against M. avium has been found. (en)
Title	High active potential antimycobacterial agents against Mycobacterium avium High active potential antimycobacterial agents against Mycobacterium avium (en)
skos:prefLabel	High active potential antimycobacterial agents against Mycobacterium avium High active potential antimycobacterial agents against Mycobacterium avium (en)
skos:notation	RIV/00216208:11160/12:10125130!RIV13-MSM-11160___
http://linked.open...avai/predkladatel	Farmaceutická fakulta v Hradci Králové
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Waisser, Karel Kuneš, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	138914
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/12:10125130
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antimycobacterial activity; Mycobacterium avium; thioxo group; benzoxazine (en)
http://linked.open.../riv/klicoveSlovo	benzoxazine thioxo group Mycobacterium avium antimycobacterial activity
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[29F32A4B5BF7]
http://linked.open...i/riv/nazevZdroje	Česká a slovenská farmacie
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	61
http://linked.open...iv/tvurceVysledku	Kuneš, Jiří Waisser, Karel Stolaříková, Jiřina
issn	1210-7816
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	11160
is http://linked.open...avai/riv/vysledek of	High active potential antimycobacterial agents against Mycobacterium avium

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