About: The influence of a carbon layer deposited on a zirconia surface on the retention of polar analytes in an organic rich mobile phase

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About: The influence of a carbon layer deposited on a zirconia surface on the retention of polar analytes in an organic rich mobile phase Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0021967311018607
Description	Hydrophilic interaction liquid chromatography (HILIC) represents a modern MS-friendly approach to the analysis of polar compounds. To date especially silica-based HILIC stationary phases are utilized. Recently the papers concerning retention of polar analytes on unmodified titania and zirconia as well as a polybutadiene modified zirconia stationary phase under HILIC conditions have been published. In this work the investigation of a highly hydrophobic carbon-coated zirconia column under HILIC conditions was reported. The influence of buffer concentration, buffer type, pH and temperature on the elution and chromatographic efficiency were studied. The processes participating on the retention of polar compounds showed a multimodal character. The retention was governed rather by surface adsorption than phase partition in high ACN mobile phases. The ligand exchange remained an important retention force although the access of the analytes to the active surface was significantly hindered by the carbon coating. Besides ligand exchange and hydrophilic interactions also the hydrophobic carbon layer was involved in the retention of carboxylic acids and especially xanthines in the organic rich mobile phase. Hydrophilic interaction liquid chromatography (HILIC) represents a modern MS-friendly approach to the analysis of polar compounds. To date especially silica-based HILIC stationary phases are utilized. Recently the papers concerning retention of polar analytes on unmodified titania and zirconia as well as a polybutadiene modified zirconia stationary phase under HILIC conditions have been published. In this work the investigation of a highly hydrophobic carbon-coated zirconia column under HILIC conditions was reported. The influence of buffer concentration, buffer type, pH and temperature on the elution and chromatographic efficiency were studied. The processes participating on the retention of polar compounds showed a multimodal character. The retention was governed rather by surface adsorption than phase partition in high ACN mobile phases. The ligand exchange remained an important retention force although the access of the analytes to the active surface was significantly hindered by the carbon coating. Besides ligand exchange and hydrophilic interactions also the hydrophobic carbon layer was involved in the retention of carboxylic acids and especially xanthines in the organic rich mobile phase. (en)
Title	The influence of a carbon layer deposited on a zirconia surface on the retention of polar analytes in an organic rich mobile phase The influence of a carbon layer deposited on a zirconia surface on the retention of polar analytes in an organic rich mobile phase (en)
skos:prefLabel	The influence of a carbon layer deposited on a zirconia surface on the retention of polar analytes in an organic rich mobile phase The influence of a carbon layer deposited on a zirconia surface on the retention of polar analytes in an organic rich mobile phase (en)
skos:notation	RIV/00216208:11160/12:10124973!RIV13-MSM-11160___
http://linked.open...avai/predkladatel	Farmaceutická fakulta v Hradci Králové
http://linked.open...avai/riv/aktivita	I S
http://linked.open...avai/riv/aktivity	I, S
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Klimeš, Jiří Kučera, Radim Kalafut, Peter
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	141308
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/12:10124973
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Ligand exchange; Carboxylates; Xanthines; Hydrophilic interaction chromatography; Zirconia; Carbon-coated zirconia (en)
http://linked.open.../riv/klicoveSlovo	Carboxylates Ligand exchange Zirconia Carbon-coated zirconia Xanthines Hydrophilic interaction chromatography
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[0B8024AF7290]
http://linked.open...i/riv/nazevZdroje	Journal of Chromatography A
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	1232
http://linked.open...iv/tvurceVysledku	Klimeš, Jiří Kučera, Radim Kalafut, Peter
http://linked.open...ain/vavai/riv/wos	000302423000031
issn	0021-9673
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.chroma.2011.12.058
http://localhost/t...ganizacniJednotka	11160
is http://linked.open...avai/riv/vysledek of	The influence of a carbon layer deposited on a zirconia surface on the retention of polar analytes in an organic rich mobile phase

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