About: The effect of the number of carbohydrate moieties on the azaphthalocyanine properties

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The effect of the number of carbohydrate moieties on the azaphthalocyanine properties Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://pubs.rsc.org/en/content/articlehtml/2012/dt/c2dt30971h
Description	A series of azaphthalocyanines (AzaPc) bearing one, two, four or eight isopropylidene-protected galactosyl units was prepared by azide-alkyne click reaction or by classical Pc template cyclotetramerization of the corresponding dicyanopyrazine and AzaPc properties important for photodynamic therapy were compared. All compounds absorbed at long wavelengths (above 650 nm) and belonged to strong singlet oxygen producers (Phi(Delta) = 0.58-0.64) retaining significant fluorescence emission (Phi(F) = 0.026-0.23). The only exception was the compound with four isopropyliden-protected galactosyl units where partial aggregation was observed. Removal of protecting groups increased the polar character of all AzaPc. However, only AzaPc bearing eight galactoses was found to be water-soluble (105 mg mL(-1)) but noticeably aggregated in water as well as in organic solvents (DMF, DMSO). Amphiphilic AzaPc bearing one deprotected galactose was incorporated into the lipidic bilayer of liposomes in a nonaggregated form. Liposomes may therefore be a suitable delivery system for this amphiphilic photosensitizer. A series of azaphthalocyanines (AzaPc) bearing one, two, four or eight isopropylidene-protected galactosyl units was prepared by azide-alkyne click reaction or by classical Pc template cyclotetramerization of the corresponding dicyanopyrazine and AzaPc properties important for photodynamic therapy were compared. All compounds absorbed at long wavelengths (above 650 nm) and belonged to strong singlet oxygen producers (Phi(Delta) = 0.58-0.64) retaining significant fluorescence emission (Phi(F) = 0.026-0.23). The only exception was the compound with four isopropyliden-protected galactosyl units where partial aggregation was observed. Removal of protecting groups increased the polar character of all AzaPc. However, only AzaPc bearing eight galactoses was found to be water-soluble (105 mg mL(-1)) but noticeably aggregated in water as well as in organic solvents (DMF, DMSO). Amphiphilic AzaPc bearing one deprotected galactose was incorporated into the lipidic bilayer of liposomes in a nonaggregated form. Liposomes may therefore be a suitable delivery system for this amphiphilic photosensitizer. (en)
Title	The effect of the number of carbohydrate moieties on the azaphthalocyanine properties The effect of the number of carbohydrate moieties on the azaphthalocyanine properties (en)
skos:prefLabel	The effect of the number of carbohydrate moieties on the azaphthalocyanine properties The effect of the number of carbohydrate moieties on the azaphthalocyanine properties (en)
skos:notation	RIV/00216208:11160/12:10124726!RIV13-MSM-11160___
http://linked.open...avai/predkladatel	Farmaceutická fakulta v Hradci Králové
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GAP207/11/1200), S
http://linked.open...iv/cisloPeriodika	35
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Nováková, Veronika Kopecký, Kamil Miletín, Miroslav Zimčík, Petr Ivincová, Jana Kučera, Radim Krepsová, Veronika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	133322
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/12:10124726
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	photosensitizers; cancer-cells; drug-delivery; quantum yields; metal-complexes; click chemistry; zinc(ii) phthalocyanines; phthalocyanine derivatives; photodynamic therapy; singlet oxygen production (en)
http://linked.open.../riv/klicoveSlovo	click chemistry photodynamic therapy cancer-cells drug-delivery photosensitizers phthalocyanine derivatives quantum yields singlet oxygen production zinc(ii) phthalocyanines metal-complexes
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[4EF24CD91BCF]
http://linked.open...i/riv/nazevZdroje	Dalton Transactions
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Red emitting photoinduced charge transfer sensors from the group of azaphthalocyanines
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	41
http://linked.open...iv/tvurceVysledku	Kopecký, Kamil Ivincová, Jana Miletín, Miroslav Nováková, Veronika Zimčík, Petr Kučera, Radim Kobak, Rabia Zeynep Uslu Krepsová, Veronika
http://linked.open...ain/vavai/riv/wos	000307592600015
issn	1477-9226
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/c2dt30971h
http://localhost/t...ganizacniJednotka	11160
is http://linked.open...avai/riv/vysledek of	The effect of the number of carbohydrate moieties on the azaphthalocyanine properties

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software