About: Synthesis and in vitro antimycobacterial activity of 2-methoxybenzanilides and their thioxo analogues

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About: Synthesis and in vitro antimycobacterial activity of 2-methoxybenzanilides and their thioxo analogues Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0223523412004709
Description	A new series of N-(3/4-substituted phenyl) 4/5-chloro-2-methoxybenzamides and their thioxo analogues have been synthesised and evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv, as well as the two atypical strains Mycobacterium kansasii and Mycobacterium avium. Five of the most active compounds were evaluated for cytotoxicity and their ability to inhibit mycobacterial isocitrate lyase, which is responsible for latent survival of Mycobacterium. The results showed that benzthioanilides were more active than the corresponding benzanilides. A new series of N-(3/4-substituted phenyl) 4/5-chloro-2-methoxybenzamides and their thioxo analogues have been synthesised and evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv, as well as the two atypical strains Mycobacterium kansasii and Mycobacterium avium. Five of the most active compounds were evaluated for cytotoxicity and their ability to inhibit mycobacterial isocitrate lyase, which is responsible for latent survival of Mycobacterium. The results showed that benzthioanilides were more active than the corresponding benzanilides. (en)
Title	Synthesis and in vitro antimycobacterial activity of 2-methoxybenzanilides and their thioxo analogues Synthesis and in vitro antimycobacterial activity of 2-methoxybenzanilides and their thioxo analogues (en)
skos:prefLabel	Synthesis and in vitro antimycobacterial activity of 2-methoxybenzanilides and their thioxo analogues Synthesis and in vitro antimycobacterial activity of 2-methoxybenzanilides and their thioxo analogues (en)
skos:notation	RIV/00216208:11160/12:10124352!RIV13-MZ0-11160___
http://linked.open...avai/predkladatel	Farmaceutická fakulta v Hradci Králové
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(NT13346), S
http://linked.open...iv/cisloPeriodika	říjen
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Volková, Marie Kozic, Ján Novotná, Eva Trejtnar, František Vinšová, Jarmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	172935
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/12:10124352
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Isocitrate lyase; Antimycobacterial activity; Benzthioanilides; Benzanilide; Tuberculosis (en)
http://linked.open.../riv/klicoveSlovo	Antimycobacterial activity Tuberculosis Isocitrate lyase Benzanilide Benzthioanilides
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[AF7B2EFDA702]
http://linked.open...i/riv/nazevZdroje	European Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Design and enzyme targeting of antibacterial active compounds against multidrug resistant strains
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	56
http://linked.open...iv/tvurceVysledku	Novotná, Eva Vinšová, Jarmila Stolaříková, Jiřina Trejtnar, František Volková, Marie Kozic, Ján
http://linked.open...ain/vavai/riv/wos	000311873600039
issn	0223-5234
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ejmech.2012.07.044
http://localhost/t...ganizacniJednotka	11160
is http://linked.open...avai/riv/vysledek of	Synthesis and in vitro antimycobacterial activity of 2-methoxybenzanilides and their thioxo analogues

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