About: Preclinical pharmacokinetics of radiolabelled hyaluronan

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About: Preclinical pharmacokinetics of radiolabelled hyaluronan Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://rabbit.if-pan.krakow.pl/pjp/pdf/2012/2_428.pdf
Description	Background: Hyaluronan (HYA) is a high molecular weight glucosaminoglycan with a great perspective for medical applications. Because HYA is widespread in the body, it is difficult to determine the fate of exogenously administered HYA. Methods: In this study, HYA of different molecular weights (0.1-1 MDa) was labelled with Tc-99m, and the distribution profiles were determined after administrating the HYA to rats. Results: After the intravenous administration of Tc-99m-HYA, a rapid decrease in the radioactivity of blood samples was observed, presumably because of Tc-99m-HYA uptake by the liver; only minimal signs of liver radioactivity washout were detected. After the oral administration of Tc-99m-HYA, no significant absorption to the central compartment was found. A preliminary study using C-14-HYA exhibited a different distribution profile than Tc-99m-HYA because of the different administered dose and the fate of the degradation products. Even with C-14-HYA, only traces of radioactivity were absorbed after oral administration. Conclusion: This paper provides quantitative information regarding the distribution parameters of radiolabelled HYA in preclinical experiments. Background: Hyaluronan (HYA) is a high molecular weight glucosaminoglycan with a great perspective for medical applications. Because HYA is widespread in the body, it is difficult to determine the fate of exogenously administered HYA. Methods: In this study, HYA of different molecular weights (0.1-1 MDa) was labelled with Tc-99m, and the distribution profiles were determined after administrating the HYA to rats. Results: After the intravenous administration of Tc-99m-HYA, a rapid decrease in the radioactivity of blood samples was observed, presumably because of Tc-99m-HYA uptake by the liver; only minimal signs of liver radioactivity washout were detected. After the oral administration of Tc-99m-HYA, no significant absorption to the central compartment was found. A preliminary study using C-14-HYA exhibited a different distribution profile than Tc-99m-HYA because of the different administered dose and the fate of the degradation products. Even with C-14-HYA, only traces of radioactivity were absorbed after oral administration. Conclusion: This paper provides quantitative information regarding the distribution parameters of radiolabelled HYA in preclinical experiments. (en)
Title	Preclinical pharmacokinetics of radiolabelled hyaluronan Preclinical pharmacokinetics of radiolabelled hyaluronan (en)
skos:prefLabel	Preclinical pharmacokinetics of radiolabelled hyaluronan Preclinical pharmacokinetics of radiolabelled hyaluronan (en)
skos:notation	RIV/00216208:11160/12:10124217!RIV13-MSM-11160___
http://linked.open...avai/predkladatel	Farmaceutická fakulta v Hradci Králové
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Lázníčková, Alice Lázníček, Milan Čožíková, Dagmar
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	160958
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/12:10124217
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pharmacokinetics; biodistribution; radiolabelling; Tc-99m; C-14; hyaluronan (en)
http://linked.open.../riv/klicoveSlovo	pharmacokinetics hyaluronan C-14 Tc-99m biodistribution radiolabelling
http://linked.open...odStatuVydavatele	PL - Polská republika
http://linked.open...ontrolniKodProRIV	[74E56B1939FF]
http://linked.open...i/riv/nazevZdroje	Pharmacological Reports
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	64
http://linked.open...iv/tvurceVysledku	Lázníček, Milan Lázníčková, Alice Čožíková, Dagmar Velebny, Vladimir
http://linked.open...ain/vavai/riv/wos	000305546700023
issn	1734-1140
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11160
is http://linked.open...avai/riv/vysledek of	Preclinical pharmacokinetics of radiolabelled hyaluronan

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