About: Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene

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About: Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0006295211006745
Description	In the report, we show a suppressive effect of metformin on PXR and other ligand-activated nuclear receptors in transactivation of the main detoxification enzyme CYP3A4 in human hepatocytes. In the report, we show a suppressive effect of metformin on PXR and other ligand-activated nuclear receptors in transactivation of the main detoxification enzyme CYP3A4 in human hepatocytes. (en)
Title	Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene (en)
skos:prefLabel	Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene (en)
skos:notation	RIV/00216208:11160/11:10100402!RIV12-GA0-11160___
http://linked.open...avai/predkladatel	Farmaceutická fakulta v Hradci Králové
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GA303/07/0128), P(GAP304/10/0149), S
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Pávek, Petr Stejskalová, Lucie Krausová, Lucie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	211750
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/11:10100402
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	AMPK; PXR; induction; cytochrome P450; metformin (en)
http://linked.open.../riv/klicoveSlovo	metformin AMPK cytochrome P450 induction PXR
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[73B17255837E]
http://linked.open...i/riv/nazevZdroje	Biochemical Pharmacology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Study on tissue-specific aspects of transcriptional regulation of selected P-450 enzymes and drug transporters. Generation of hepatocyte-derived cellular models for preclinical testing of drugs
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	82
http://linked.open...iv/tvurceVysledku	Dvořák, Zdeněk Pávek, Petr Vrzal, Radim Stejskalová, Lucie Krausová, Lucie Mani, Sridhar Wang, Hongwei
http://linked.open...ain/vavai/riv/wos	000296931400026
issn	0006-2952
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bcp.2011.08.023
http://localhost/t...ganizacniJednotka	11160
is http://linked.open...avai/riv/vysledek of	Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene

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