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  • Oxime-type AChE reactivators pralidoxime, obidoxime, trimedoxime, methoxime and HI-6 were tested for their potential to affect the activity of monoamine oxidase of type A (MAO-A) and type B (MAO-B) in crude mitochondrial fraction of pig brains. The in vitro potency of oximes to change MAO activity seems to be weak; hence, all oximes tested can be taken as relatively safe compounds regarding to drug-induced changes in MAO activity and related changes in monoaminergic neurotransmission.
  • Oxime-type AChE reactivators pralidoxime, obidoxime, trimedoxime, methoxime and HI-6 were tested for their potential to affect the activity of monoamine oxidase of type A (MAO-A) and type B (MAO-B) in crude mitochondrial fraction of pig brains. The in vitro potency of oximes to change MAO activity seems to be weak; hence, all oximes tested can be taken as relatively safe compounds regarding to drug-induced changes in MAO activity and related changes in monoaminergic neurotransmission. (en)
Title
  • In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity
  • In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity (en)
skos:prefLabel
  • In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity
  • In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity (en)
skos:notation
  • RIV/00216208:11160/11:10099815!RIV12-MSM-11160___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
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  • S, Z(MSM0021620849)
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  • 2
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http://linked.open...aciTvurceVysledku
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  • 204037
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11160/11:10099815
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • HI-6; methoxime; trimedoxime; obidoxime; pralidoxime; oxime; monoamino oxidase (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [D394F1CB0909]
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  • Toxicology Letters
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  • 201
http://linked.open...iv/tvurceVysledku
  • Fišar, Zdeněk
  • Hroudová, Jana
  • Kuča, Kamil
  • Musílek, Kamil
  • Korábečný, Jan
http://linked.open...ain/vavai/riv/wos
  • 000288342000010
http://linked.open...n/vavai/riv/zamer
issn
  • 0378-4274
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.toxlet.2010.12.023
http://localhost/t...ganizacniJednotka
  • 11160
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