About: Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma

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About: Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In our project we try to characterize the effect of phytic acid (IP6) as a potential adjuvant in treatment of colorectal carcinoma. There is some evidence that myo-inositol (Ins) can potentiate anticancer effects of IP6. Therefore we tested both IP6 and Ins individually and in combination on human cell lines HT-29, SW-480 and SW-620 derived from the colorectal carcinoma in different stages of malignancy. The effect of tested chemicals on the cells was measured using WST, BrdU, Brilliant Blue and caspase-3 activity. We tested IP6 and Ins at three concentrations: 0.2, 1 and 5 mM during 24, 48 and 72 hours. We found that all employed concentrations of IP6 or IP6/Ins decreased proliferation of all cell lines. Metabolic activity and protein content of treated cells differed in response to IP6 and IP6/Ins treatment. We found the maximum increase in caspase-3 activity in HT-29 (5mM) and in SW480 (0,2 mM) with clear indication of Ins enhancing the proapoptotic effect of IP6 in all cell lines. In our project we try to characterize the effect of phytic acid (IP6) as a potential adjuvant in treatment of colorectal carcinoma. There is some evidence that myo-inositol (Ins) can potentiate anticancer effects of IP6. Therefore we tested both IP6 and Ins individually and in combination on human cell lines HT-29, SW-480 and SW-620 derived from the colorectal carcinoma in different stages of malignancy. The effect of tested chemicals on the cells was measured using WST, BrdU, Brilliant Blue and caspase-3 activity. We tested IP6 and Ins at three concentrations: 0.2, 1 and 5 mM during 24, 48 and 72 hours. We found that all employed concentrations of IP6 or IP6/Ins decreased proliferation of all cell lines. Metabolic activity and protein content of treated cells differed in response to IP6 and IP6/Ins treatment. We found the maximum increase in caspase-3 activity in HT-29 (5mM) and in SW480 (0,2 mM) with clear indication of Ins enhancing the proapoptotic effect of IP6 in all cell lines. (en)
Title	Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma (en)
skos:prefLabel	Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma (en)
skos:notation	RIV/00216208:11160/10:00300544!RIV11-MSM-11160___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hašková, Pavlína
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	256099
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/10:00300544
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	phytic acid; inositol; colorectal cancer; apoptosis; proliferation (en)
http://linked.open.../riv/klicoveSlovo	inositol colorectal cancer apoptosis proliferation phytic acid
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[8864252F5D46]
http://linked.open...i/riv/nazevZdroje	Oncology Reports
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Hašková, Pavlína Rudolf, Emil Červinka, Miroslav Schröterová, Ladislava
http://linked.open...ain/vavai/riv/wos	000275226100026
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	1021-335X
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11160
is http://linked.open...avai/riv/vysledek of	Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma

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