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  • Cardiotoxicity is a serious side effect ot the anthracycline anticancer chemotherapy. We have searched for the cardioprotective agents that combine iron-chelating and antioxidant properties. After an extensive /in vitro/ screening it has been found that flavonoids and especially 7-monohydroxyethylrutoside could serve this purpose. 7-monohydroxyethylrutoside also efficiently prevented doxorubicin cardiotoxicity in mice and was found to be safe to be investigated in humans in a study with healthy volunteers.
  • Cardiotoxicity is a serious side effect ot the anthracycline anticancer chemotherapy. We have searched for the cardioprotective agents that combine iron-chelating and antioxidant properties. After an extensive /in vitro/ screening it has been found that flavonoids and especially 7-monohydroxyethylrutoside could serve this purpose. 7-monohydroxyethylrutoside also efficiently prevented doxorubicin cardiotoxicity in mice and was found to be safe to be investigated in humans in a study with healthy volunteers. (en)
  • Kardiotoxicita je závažný nežádoucí účinek antracyklinové protinádorové terapie. Hledali jsme kardioprotektivní látky, které kombinují železe-chelatující a antioxidační vlastnosti. Po rozsáhlém /in vitro/ screeningu bylo zjištěno, že flavonoidy a zvláště pak 7-monohydroxyetylrutosid tyto požadavky splňují. 7-monohydroxyetylrutoside rovněž účinně předcházel doxorubicinové kardiotoxicitě v /in vivo/ studii na myších a byl shledán bezpečným v pilotní klinické studii na zdravých dobrovolnících. (cs)
Title
  • Protectors against doxorubicin-induced cardiotoxicity: Flavonoids
  • Protektiva proti doxorubicinové kardiotoxicitě: Flavonoidy (cs)
  • Protectors against doxorubicin-induced cardiotoxicity: Flavonoids (en)
skos:prefLabel
  • Protectors against doxorubicin-induced cardiotoxicity: Flavonoids
  • Protektiva proti doxorubicinové kardiotoxicitě: Flavonoidy (cs)
  • Protectors against doxorubicin-induced cardiotoxicity: Flavonoids (en)
skos:notation
  • RIV/00216208:11160/07:00006778!RIV08-MSM-11160___
http://linked.open.../vavai/riv/strany
  • 39;47
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http://linked.open...dnocenehoVysledku
  • 445546
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11160/07:00006778
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Protectors; against; doxorubicin-induced; cardiotoxicity; Flavonoids (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [66155E198A4E]
http://linked.open...i/riv/nazevZdroje
  • Cell Biology and Toxicology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 23
http://linked.open...iv/tvurceVysledku
  • Kaiserová, Helena
issn
  • 0742-2091
number of pages
http://localhost/t...ganizacniJednotka
  • 11160
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