About: DOTA-Tyr(3)-octreotate radiolabelled with 111-In: Stability and the effect of receptor-specific binding on distribution

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About: DOTA-Tyr(3)-octreotate radiolabelled with 111-In: Stability and the effect of receptor-specific binding on distribution Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Radiolabeling, stability and pharmacokinetic analysis in rats of 111-In-DOTA-Tyr(3)-octreotate were studied. Radiolabeling of the peptide is simple and high radiolabeling yields were achieved. The agent was stable in in vivo conditions; the radioactivity eliminated by urine was nearly completely in the parent form. The affinity of the agent to somatostatin receptor-rich organs was substantially higher than that of commercially available 111-In-DTPA-octreotide (OctreoScan). The study confirmed high in vivo affinity of the peptide to somatostatin receptors and revealed that receptor binding alters both, distribution profile and elimination pathways of the agent in preclinical experiments. Radiolabeling, stability and pharmacokinetic analysis in rats of 111-In-DOTA-Tyr(3)-octreotate were studied. Radiolabeling of the peptide is simple and high radiolabeling yields were achieved. The agent was stable in in vivo conditions; the radioactivity eliminated by urine was nearly completely in the parent form. The affinity of the agent to somatostatin receptor-rich organs was substantially higher than that of commercially available 111-In-DTPA-octreotide (OctreoScan). The study confirmed high in vivo affinity of the peptide to somatostatin receptors and revealed that receptor binding alters both, distribution profile and elimination pathways of the agent in preclinical experiments. (en) Bylo studováno radioaktivní značení, stabilita a farmakokinetika 111-In-DOTA-Tyr(3)-oktreotátu u krys. Radioaktivní značení peptide je jednoduché s vysokým výtěžkem značení. Látka byla stabilní v in vivo podmínkách; radioaktivita eliminovaná močí byla prakticky kompletně ve formě parentní látky. Afinita značeného peptidu k orgánům s vysokou hustotou somatostatinových receptorů byla podstatně vyšší než u komerčně dostupného 111-In-DTPA-octreotidu (OctreoScan). Studie potvrdila vysokou in vivo afinitu peptidu k somatostatinovým receptorům a ukázala, že receptorová vazba ovlivňuje distribuční profil a eliminační cesty značeného peptide v předklinickém experimentu. (cs)
Title	DOTA-Tyr(3)-octreotate radiolabelled with 111-In: Stability and the effect of receptor-specific binding on distribution DOTA-Tyr(3)-oktreotát radioaktivně značený 111-In: Stabilita a vliv receptorově-specifické vazby na distribuci (cs) DOTA-Tyr(3)-octreotate radiolabelled with 111-In: Stability and the effect of receptor-specific binding on distribution (en)
skos:prefLabel	DOTA-Tyr(3)-octreotate radiolabelled with 111-In: Stability and the effect of receptor-specific binding on distribution DOTA-Tyr(3)-oktreotát radioaktivně značený 111-In: Stabilita a vliv receptorově-specifické vazby na distribuci (cs) DOTA-Tyr(3)-octreotate radiolabelled with 111-In: Stability and the effect of receptor-specific binding on distribution (en)
skos:notation	RIV/00216208:11160/07:00006643!RIV08-MSM-11160___
http://linked.open.../vavai/riv/strany	587;597
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Syrovátko, Matěj Lázníčková, Alice Lázníček, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	418067
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/07:00006643
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DOTA-Tyr; -octreotate; radiolabelled; 111-In; Stability; effect; receptor-specific; binding; distribution (en)
http://linked.open.../riv/klicoveSlovo	effect distribution receptor-specific -octreotate 111-In DOTA-Tyr radiolabelled Stability binding
http://linked.open...odStatuVydavatele	HU - Maďarsko
http://linked.open...ontrolniKodProRIV	[B4A5BDA75173]
http://linked.open...i/riv/nazevZdroje	Journal of Radioanalytical and Nuclear Chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	273
http://linked.open...iv/tvurceVysledku	Lázníček, Milan Lázníčková, Alice Syrovátko, Matěj
issn	0236-5731
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	11160
is http://linked.open...avai/riv/vysledek of	DOTA-Tyr(3)-octreotate radiolabelled with 111-In: Stability and the effect of receptor-specific binding on distribution DOTA-Tyr(3)-octreotate radiolabelled with 111-In: Stability and the effect of receptor-specific binding on distribution DOTA-Tyr(3)-octreotate radiolabelled with 111-In: Stability and the effect of receptor-specific binding on distribution

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