About: Ring-functionalized niobocene complexes     Goto   Sponge   NotDistinct   Permalink

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Description
  • A series of new ring-functionalized niobocene dichloride compounds (RCH2C5H4)2NbCl2 (R = MeOCH2, (CH2)5NCH2, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 2,4-(MeO)2C6H3, 3,4-(MeO)2C6H3, 2,4,6-(MeO)3C6H2, 3,4,5-(MeO)3C6H2, 4-FC6H4, 4-Me2NC6H4) was synthesized and characterized by electron paramagnetic resonance. Three structures were determined by X-ray diffraction analysis and revealed the expected bent metallocene structure with two cyclopentadienyl ligands and two chlorides coordinated to niobium in the oxidation state IV. Chlorides and the centroids of the η5-bonded cyclopentadienyl rings define a distorted tetrahedron. The cytotoxicity study has demonstrated that substitution with methoxybenzyl groups can lead to highly active species, but the activity strongly varies with the number and positions of the methoxy groups in the benzene ring. The most active species under study - {2,4-(MeO)2C6H3CH2C5H4}2NbCl2 - has a maximal inhibitory concentration value comparable with cisplatin.
  • A series of new ring-functionalized niobocene dichloride compounds (RCH2C5H4)2NbCl2 (R = MeOCH2, (CH2)5NCH2, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 2,4-(MeO)2C6H3, 3,4-(MeO)2C6H3, 2,4,6-(MeO)3C6H2, 3,4,5-(MeO)3C6H2, 4-FC6H4, 4-Me2NC6H4) was synthesized and characterized by electron paramagnetic resonance. Three structures were determined by X-ray diffraction analysis and revealed the expected bent metallocene structure with two cyclopentadienyl ligands and two chlorides coordinated to niobium in the oxidation state IV. Chlorides and the centroids of the η5-bonded cyclopentadienyl rings define a distorted tetrahedron. The cytotoxicity study has demonstrated that substitution with methoxybenzyl groups can lead to highly active species, but the activity strongly varies with the number and positions of the methoxy groups in the benzene ring. The most active species under study - {2,4-(MeO)2C6H3CH2C5H4}2NbCl2 - has a maximal inhibitory concentration value comparable with cisplatin. (en)
Title
  • Ring-functionalized niobocene complexes
  • Ring-functionalized niobocene complexes (en)
skos:prefLabel
  • Ring-functionalized niobocene complexes
  • Ring-functionalized niobocene complexes (en)
skos:notation
  • RIV/00216208:11150/14:10283558!RIV15-MSM-11150___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 42781
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11150/14:10283558
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • leukemia therapy; X-ray diffraction analysis; EPR spectroscopy; cytotoxicity; Metallocene dihalides (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [BD3F064FF483]
http://linked.open...i/riv/nazevZdroje
  • Applied Organometallic Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 28
http://linked.open...iv/tvurceVysledku
  • Padělková, Zdeňka
  • Vinklárek, Jaromír
  • Řezáčová, Martina
  • Honzíček, Jan
  • Šebestová, Lucie
  • Honzíčková, Iva
http://linked.open...ain/vavai/riv/wos
  • 000333043000008
issn
  • 0268-2605
number of pages
http://bibframe.org/vocab/doi
  • 10.1002/aoc.3117
http://localhost/t...ganizacniJednotka
  • 11150
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