About: Melatonin reduces cardiac remodeling and improves survival in rats with isoproterenol-induced heart failure

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About: Melatonin reduces cardiac remodeling and improves survival in rats with isoproterenol-induced heart failure Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1111/jpi.12154/pdf
Description	Melatonin was previously shown to reduce blood pressure and left ventricular remodeling in several models of experimental heart damage. Isoproterenol-induced heart failure with hypertrophy of the left and right ventricles, lowered systolic blood pressure and elevated pulmonary congestion. Fibrotic rebuilding was accompanied by alterations of tubulin level in the LV and oxidative stress development. Melatonin failed to reduce the weight of the LV or RV; however, it curtailed the weight of the lungs and attenuated the decline in SBP. Moreover, melatonin decreased the level of oxidative stress and insoluble and total collagen. Most importantly, melatonin reduced mortality and prolonged the average survival time. In conclusion, melatonin exerts cardioprotective effects and improves outcome in a model of isoproterenol-induced heart damage. Melatonin was previously shown to reduce blood pressure and left ventricular remodeling in several models of experimental heart damage. Isoproterenol-induced heart failure with hypertrophy of the left and right ventricles, lowered systolic blood pressure and elevated pulmonary congestion. Fibrotic rebuilding was accompanied by alterations of tubulin level in the LV and oxidative stress development. Melatonin failed to reduce the weight of the LV or RV; however, it curtailed the weight of the lungs and attenuated the decline in SBP. Moreover, melatonin decreased the level of oxidative stress and insoluble and total collagen. Most importantly, melatonin reduced mortality and prolonged the average survival time. In conclusion, melatonin exerts cardioprotective effects and improves outcome in a model of isoproterenol-induced heart damage. (en)
Title	Melatonin reduces cardiac remodeling and improves survival in rats with isoproterenol-induced heart failure Melatonin reduces cardiac remodeling and improves survival in rats with isoproterenol-induced heart failure (en)
skos:prefLabel	Melatonin reduces cardiac remodeling and improves survival in rats with isoproterenol-induced heart failure Melatonin reduces cardiac remodeling and improves survival in rats with isoproterenol-induced heart failure (en)
skos:notation	RIV/00216208:11150/14:10271859!RIV15-MSM-11150___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Adamcová, Michaela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	28242
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/14:10271859
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	remodeling; mortality; melatonin; isoproterenol; heart hypertrophy; heart failure; fibrosis (en)
http://linked.open.../riv/klicoveSlovo	remodeling heart failure melatonin mortality fibrosis heart hypertrophy isoproterenol
http://linked.open...odStatuVydavatele	DK - Dánské království
http://linked.open...ontrolniKodProRIV	[9C0F4689E1CF]
http://linked.open...i/riv/nazevZdroje	Journal of Pineal Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	57
http://linked.open...iv/tvurceVysledku	Adamcová, Michaela Celec, Peter Šimko, Fedor Kamodyová, Natalia Krajčirovičová, Kristina Repová-Bednárová, Kristina Zorad, Štefan Gajdosechová, Lucia Hrenak, Jaroslav
http://linked.open...ain/vavai/riv/wos	000342234000005
issn	0742-3098
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/jpi.12154
http://localhost/t...ganizacniJednotka	11150

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