About: The effect of epigallocatechin gallate on hepatocytes isolated from normal and partially hepatectomized rats

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About: The effect of epigallocatechin gallate on hepatocytes isolated from normal and partially hepatectomized rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.nrcresearchpress.com/doi/abs/10.1139/cjpp-2014-0069#.U-takxAQcvk
Description	Epigallocatechin gallate (EGCG) is an antioxidant found in green tea. In this study, male Wistar rats were subjected either to partial hepatectomy (PHx), or a sham operation (LAP). Twenty-four hours after surgery, hepatocytes were isolated and treated with various concentrations of EGCG for up to 72 h. We then measured markers of cell viability, oxidative stress, DNA synthesis, and caspase activity. Morphological criteria, cell viability tests, and albumin synthesis revealed toxicity starting at 10 μmol/L. DNA synthesis was higher in hepatocytes isolated from rats after PHx and inhibited by EGCG. Furthermore, EGCG increased the activity of caspases 3 and 7, seen more in hepatocytes from PHx rats. In conclusion, EGCG at a concentration of 10 μmol/L was toxic for hepatocytes isolated from both PHx and LAP rats. Epigallocatechin gallate (EGCG) is an antioxidant found in green tea. In this study, male Wistar rats were subjected either to partial hepatectomy (PHx), or a sham operation (LAP). Twenty-four hours after surgery, hepatocytes were isolated and treated with various concentrations of EGCG for up to 72 h. We then measured markers of cell viability, oxidative stress, DNA synthesis, and caspase activity. Morphological criteria, cell viability tests, and albumin synthesis revealed toxicity starting at 10 μmol/L. DNA synthesis was higher in hepatocytes isolated from rats after PHx and inhibited by EGCG. Furthermore, EGCG increased the activity of caspases 3 and 7, seen more in hepatocytes from PHx rats. In conclusion, EGCG at a concentration of 10 μmol/L was toxic for hepatocytes isolated from both PHx and LAP rats. (en)
Title	The effect of epigallocatechin gallate on hepatocytes isolated from normal and partially hepatectomized rats The effect of epigallocatechin gallate on hepatocytes isolated from normal and partially hepatectomized rats (en)
skos:prefLabel	The effect of epigallocatechin gallate on hepatocytes isolated from normal and partially hepatectomized rats The effect of epigallocatechin gallate on hepatocytes isolated from normal and partially hepatectomized rats (en)
skos:notation	RIV/00216208:11150/14:10218611!RIV15-MSM-11150___
http://linked.open...avai/riv/aktivita	I S
http://linked.open...avai/riv/aktivity	I, S
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Červinková, Zuzana Kučera, Otto Peterová, Eva Mezera, Vojtěch Moravcová, Alena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	13252
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/14:10218611
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	primary cell culture; oxidative stress; liver regeneration; hepatocytes; hepatectomy; epigallocatechin gallate; catechin; apoptosis; antioxidants (en)
http://linked.open.../riv/klicoveSlovo	primary cell culture hepatectomy catechin antioxidants epigallocatechin gallate apoptosis hepatocytes oxidative stress liver regeneration
http://linked.open...odStatuVydavatele	CA - Kanada
http://linked.open...ontrolniKodProRIV	[304A8473A6D7]
http://linked.open...i/riv/nazevZdroje	Canadian Journal of Physiology and Pharmacology
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	92
http://linked.open...iv/tvurceVysledku	Kučera, Otto Červinková, Zuzana Moravcová, Alena Mezera, Vojtěch Peterová, Eva
http://linked.open...ain/vavai/riv/wos	000338712700013
issn	0008-4212
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1139/cjpp-2014-0069
http://localhost/t...ganizacniJednotka	11150

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