About: Estradiol receptors agonists induced effects in rat intestinal microcirculation during sepsis

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About: Estradiol receptors agonists induced effects in rat intestinal microcirculation during sepsis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.mvr.2012.10.002
Description	The present study suggests that the intestinal microcirculation in experimental sepsis can be modulated by estradiol receptor agonists.These findings might explain the relative resistance of the female gastrointestinal barrier function to systemic inflammation.Estradiol receptors agonists represent a novel alternative for experimental treatment with the non-selective steroid hormone estradiol in sepsis.However,further studies are needed to provide additional,mechanistic information to understand the effects of estradiol receptor agonists.The use of such agonists would be beneficial as it might avoid the side effects reported after estradiol hormone therapy. The present study suggests that the intestinal microcirculation in experimental sepsis can be modulated by estradiol receptor agonists.These findings might explain the relative resistance of the female gastrointestinal barrier function to systemic inflammation.Estradiol receptors agonists represent a novel alternative for experimental treatment with the non-selective steroid hormone estradiol in sepsis.However,further studies are needed to provide additional,mechanistic information to understand the effects of estradiol receptor agonists.The use of such agonists would be beneficial as it might avoid the side effects reported after estradiol hormone therapy. (en)
Title	Estradiol receptors agonists induced effects in rat intestinal microcirculation during sepsis Estradiol receptors agonists induced effects in rat intestinal microcirculation during sepsis (en)
skos:prefLabel	Estradiol receptors agonists induced effects in rat intestinal microcirculation during sepsis Estradiol receptors agonists induced effects in rat intestinal microcirculation during sepsis (en)
skos:notation	RIV/00216208:11150/13:10194859!RIV14-MSM-11150___
http://linked.open...avai/predkladatel	Lékařská fakulta v Hradci Králové
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	January 2013
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Černý, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	73310
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/13:10194859
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lung injury; cecal ligation; inflammatory response; bacterial translocation; blood-flow; polymicrobial sepsis; nitric-oxide; trauma-hemorrhage; estrogen-receptor; ascendens stent peritonitis (en)
http://linked.open.../riv/klicoveSlovo	bacterial translocation ascendens stent peritonitis polymicrobial sepsis trauma-hemorrhage nitric-oxide estrogen-receptor cecal ligation inflammatory response lung injury blood-flow
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CDFF5111E6B4]
http://linked.open...i/riv/nazevZdroje	Microvascular Research
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	85
http://linked.open...iv/tvurceVysledku	Černý, Vladimír Lehmann, Christian Pavlovic, Dragan Sharawy, Nivin Wendt, Michael Kern, Hartmut Al-Banna, Nadia Dombrowski, Frank Ribback, Silvia
http://linked.open...ain/vavai/riv/wos	000314318800017
issn	0026-2862
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.mvr.2012.10.002
http://localhost/t...ganizacniJednotka	11150

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