About: The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery     Goto   Sponge   NotDistinct   Permalink

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  • Coronary artery bypass grafting (CABG) is performed with the use of cardiopulmonary bypass (CPB) and cardioplegic arrest (CA) of the heart. The advantage of this technique, alternatively referred to as %22on-pump%22 surgery, resides, for the surgeon, in relatively easy access to and manipulation with the non-beating, bloodless heart. However, the advantage that is, thereby, gained by the patient is paid off by an increased susceptibility to postoperative systemic inflammatory response syndrome (SIRS). Under unfavorable conditions, the inflammatory syndrome may develop into life-threatening forms of MODS (multiple organ dysfunction syndrome) or even MOFS (multiple organ failure syndrome). Deliberate avoidance of CPB, also known as %22off-pump%22 surgery, attenuates early postoperative inflammation throughout its trajectory of SIRSRIGHTWARDS ARROWMODSRIGHTWARDS ARROWMOFS, but, in the long run, there appears to be no substantial difference in the overall mortality rates. In the last years, our knowledge of the pathophysiology of surgical inflammation has increased considerably. Recent findings, highlighting the as yet rather obscure role of pentraxin 3 (PTX3) in these processes, are discussed in this review article.
  • Coronary artery bypass grafting (CABG) is performed with the use of cardiopulmonary bypass (CPB) and cardioplegic arrest (CA) of the heart. The advantage of this technique, alternatively referred to as %22on-pump%22 surgery, resides, for the surgeon, in relatively easy access to and manipulation with the non-beating, bloodless heart. However, the advantage that is, thereby, gained by the patient is paid off by an increased susceptibility to postoperative systemic inflammatory response syndrome (SIRS). Under unfavorable conditions, the inflammatory syndrome may develop into life-threatening forms of MODS (multiple organ dysfunction syndrome) or even MOFS (multiple organ failure syndrome). Deliberate avoidance of CPB, also known as %22off-pump%22 surgery, attenuates early postoperative inflammation throughout its trajectory of SIRSRIGHTWARDS ARROWMODSRIGHTWARDS ARROWMOFS, but, in the long run, there appears to be no substantial difference in the overall mortality rates. In the last years, our knowledge of the pathophysiology of surgical inflammation has increased considerably. Recent findings, highlighting the as yet rather obscure role of pentraxin 3 (PTX3) in these processes, are discussed in this review article. (en)
Title
  • The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery
  • The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery (en)
skos:prefLabel
  • The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery
  • The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery (en)
skos:notation
  • RIV/00216208:11150/13:10139197!RIV14-MSM-11150___
http://linked.open...avai/predkladatel
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http://linked.open...iv/cisloPeriodika
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  • 85351
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11150/13:10139197
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • interleukin-10; pentraxin 3; alarmins; sterile inflammation; cardiopulmonary bypass; coronary artery bypass grafting (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [C7BD407125B9]
http://linked.open...i/riv/nazevZdroje
  • Perfusion
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...v/svazekPeriodika
  • 28
http://linked.open...iv/tvurceVysledku
  • Krejsek, Jan
  • Koláčková, Martina
  • Manďák, Jiří
  • Kuneš, Pavel
  • Holubcová, Zdeňka
http://linked.open...ain/vavai/riv/wos
  • 000323311800002
issn
  • 0267-6591
number of pages
http://bibframe.org/vocab/doi
  • 10.1177/0267659113483799
http://localhost/t...ganizacniJednotka
  • 11150
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