About: Methylation in the p53 promoter in epithelial ovarian cancer

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://link.springer.com/article/10.1007%2Fs12094-012-0894-z
Description	Ovarian cancer is a leading cause of death from gynecologic tumors, however epigenetic events underlying this transformation are poorly understood. Promoter methylation status of tumor suppressor genes may be associated with transcriptional silencing and tumor progression. It has been shown that methylation located in the promoter region of p53 is associated with low expression of this gene. The aim of this study was to investigate promoter methylation of p53 gene in ovarian cancer by comparison with normal ovarian tissue. We used methylation-specific PCR to compare the methylation status of p53 promoter of 66 tissue samples of ovarian cancer with 37 control samples. In our study methylation specific PCR revealed p53 promoter methylation in 34 of 66 (51.5 %) of specimens with ovarian cancer. These results indicate that methylation in p53 promoter region may play an important role in carcinogenesis of ovarian cancer. Ovarian cancer is a leading cause of death from gynecologic tumors, however epigenetic events underlying this transformation are poorly understood. Promoter methylation status of tumor suppressor genes may be associated with transcriptional silencing and tumor progression. It has been shown that methylation located in the promoter region of p53 is associated with low expression of this gene. The aim of this study was to investigate promoter methylation of p53 gene in ovarian cancer by comparison with normal ovarian tissue. We used methylation-specific PCR to compare the methylation status of p53 promoter of 66 tissue samples of ovarian cancer with 37 control samples. In our study methylation specific PCR revealed p53 promoter methylation in 34 of 66 (51.5 %) of specimens with ovarian cancer. These results indicate that methylation in p53 promoter region may play an important role in carcinogenesis of ovarian cancer. (en)
Title	Methylation in the p53 promoter in epithelial ovarian cancer Methylation in the p53 promoter in epithelial ovarian cancer (en)
skos:prefLabel	Methylation in the p53 promoter in epithelial ovarian cancer Methylation in the p53 promoter in epithelial ovarian cancer (en)
skos:notation	RIV/00216208:11150/13:10126505!RIV14-MSM-11150___
http://linked.open...avai/predkladatel	Lékařská fakulta v Hradci Králové
http://linked.open...avai/riv/aktivita	I S
http://linked.open...avai/riv/aktivity	I, S
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Chmelařová, Marcela Palička, Vladimír Laco, Jan Špaček, Jiří Dvořáková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	87657
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/13:10126505
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ovarian cancer; promoter methylation; p53 (en)
http://linked.open.../riv/klicoveSlovo	promoter methylation p53 ovarian cancer
http://linked.open...odStatuVydavatele	ES - Španělské království
http://linked.open...ontrolniKodProRIV	[D17E516AC46E]
http://linked.open...i/riv/nazevZdroje	Clinical and Translational Oncology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Beránek, Martin Chmelařová, Marcela Laco, Jan Palička, Vladimír Špaček, Jiří Křepinská, Eva
http://linked.open...ain/vavai/riv/wos	000314280500011
issn	1699-048X
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s12094-012-0894-z
http://localhost/t...ganizacniJednotka	11150

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