About: Affinity maturation of antibodies requires integrity of the adult thymus     Goto   Sponge   NotDistinct   Permalink

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  • The generation of B-cell responses to proteins requires a functional thymus to produce CD4+ T cells which helps in the activation and differentiation of B cells. Because the mature T-cell repertoire has abundant cells with the helper phenotype, one might predict that in mature individuals, the generation of B-cell memory would proceed independently of the thymus. Contrary to that prediction, we show here that the removal of the thymus after the establishment of the T-cell compartment or sham surgery without removal of the thymus impairs the affinity maturation of antibodies. Because removal or manipulation of the thymus did not decrease the frequency of mutation of the Ig variable heavy chain exons encoding antigen-specific antibodies, we conclude that the thymus controls affinity maturation of antibodies in the mature individual by facilitating the selection of B cells with high-affinity antibodies.
  • The generation of B-cell responses to proteins requires a functional thymus to produce CD4+ T cells which helps in the activation and differentiation of B cells. Because the mature T-cell repertoire has abundant cells with the helper phenotype, one might predict that in mature individuals, the generation of B-cell memory would proceed independently of the thymus. Contrary to that prediction, we show here that the removal of the thymus after the establishment of the T-cell compartment or sham surgery without removal of the thymus impairs the affinity maturation of antibodies. Because removal or manipulation of the thymus did not decrease the frequency of mutation of the Ig variable heavy chain exons encoding antigen-specific antibodies, we conclude that the thymus controls affinity maturation of antibodies in the mature individual by facilitating the selection of B cells with high-affinity antibodies. (en)
Title
  • Affinity maturation of antibodies requires integrity of the adult thymus
  • Affinity maturation of antibodies requires integrity of the adult thymus (en)
skos:prefLabel
  • Affinity maturation of antibodies requires integrity of the adult thymus
  • Affinity maturation of antibodies requires integrity of the adult thymus (en)
skos:notation
  • RIV/00216208:11150/12:10210283!RIV14-MSM-11150___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
  • AbuAttieh, Mouhammed O.
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 121260
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11150/12:10210283
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Thymus; T-cell repertoire; Immunoglobulin; Antibody-secreting cells; Affinity maturation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [30329D6F3A9C]
http://linked.open...i/riv/nazevZdroje
  • European Journal of Immunology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 42
http://linked.open...iv/tvurceVysledku
  • AbuAttieh, Mouhammed O.
  • Bender, Diane
  • Cascalho, Marilia
  • Liu, Esther
  • Platt, Jeffrey L.
  • Wettstein, Peter
http://linked.open...ain/vavai/riv/wos
  • 000299337800025
issn
  • 0014-2980
number of pages
http://bibframe.org/vocab/doi
  • 10.1002/eji.201141889
http://localhost/t...ganizacniJednotka
  • 11150
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