About: Paricalcitol (19-nor-1,25-dihydroxycholecalciferol) and calcitriol (1,25-dihydroxycholecalciferol) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells

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About: Paricalcitol (19-nor-1,25-dihydroxycholecalciferol) and calcitriol (1,25-dihydroxycholecalciferol) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this study we show that, in all investigated aspects, paricalcitol retains significant immunomodulatory activity, comparable to calcitriol. Both VDR agonists impaired differentiation of immature dendritic cells (DCs) from monocytes. The presence of VDR agonists during DC differentiation abolished their capacity to be activated and, despite potent Toll-like receptor mediated stimulation, VDR agonist-treated DCs remained in the immature state. The immunomodulatory potency of paricalcitol makes it a drug of interest in the therapy of chronic immune-mediated inflammatory diseases In this study we show that, in all investigated aspects, paricalcitol retains significant immunomodulatory activity, comparable to calcitriol. Both VDR agonists impaired differentiation of immature dendritic cells (DCs) from monocytes. The presence of VDR agonists during DC differentiation abolished their capacity to be activated and, despite potent Toll-like receptor mediated stimulation, VDR agonist-treated DCs remained in the immature state. The immunomodulatory potency of paricalcitol makes it a drug of interest in the therapy of chronic immune-mediated inflammatory diseases (en)
Title	Paricalcitol (19-nor-1,25-dihydroxycholecalciferol) and calcitriol (1,25-dihydroxycholecalciferol) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells Paricalcitol (19-nor-1,25-dihydroxycholecalciferol) and calcitriol (1,25-dihydroxycholecalciferol) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells (en)
skos:prefLabel	Paricalcitol (19-nor-1,25-dihydroxycholecalciferol) and calcitriol (1,25-dihydroxycholecalciferol) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells Paricalcitol (19-nor-1,25-dihydroxycholecalciferol) and calcitriol (1,25-dihydroxycholecalciferol) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells (en)
skos:notation	RIV/00216208:11150/09:00208747!RIV10-MSM-11150___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM0021620812), Z(MSM0021620819)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Dusilová - Sulková, Sylvie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	332705
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/09:00208747
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Immunomodulatory effect; Vitamin D; VDR activators; Paricalcitol; Calcitriol; Dendritic cell; Chronic kidney disease (en)
http://linked.open.../riv/klicoveSlovo	Chronic kidney disease Calcitriol Dendritic cell Immunomodulatory effect Paricalcitol VDR activators Vitamin D
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DFF275C7F60F]
http://linked.open...i/riv/nazevZdroje	Clinical Immunology
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	133
http://linked.open...iv/tvurceVysledku	Špíšek, Radek Rožková, Daniela Bartůňková, Jiřina Budinský, Vít Sochorová, Klára Dusilová-Sulková, Sylvie Tobiasová, Zuzana
http://linked.open...ain/vavai/riv/wos	000270292400008
http://linked.open...n/vavai/riv/zamer	Chronická onemocnění vznikající na podkladě nepřiměřené reaktivity imunitního systému, jejich patogeneze a možnosti včasné diagnostiky a léčby Náhrada a podpora funkce některých životně důležitých orgánů
issn	1521-6616
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	11150
is http://linked.open...avai/riv/vysledek of	Paricalcitol (19-nor-1,25-dihydroxycholecalciferol) and calcitriol (1,25-dihydroxycholecalciferol) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells Paricalcitol (19-nor-1,25-dihydroxycholecalciferol) and calcitriol (1,25-dihydroxycholecalciferol) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells Paricalcitol (19-nor-1,25-dihydroxycholecalciferol) and calcitriol (1,25-dihydroxycholecalciferol) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells Paricalcitol (19-nor-1,25-dihydroxycholecalciferol) and calcitriol (1,25-dihydroxycholecalciferol) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells

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