About: Genotoxic Hazard and Cellular Stress in Pediatric Patients Treated for Psoriasis with the Goeckerman Regimen

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The Goeckerman regimen (GR) represents a local treatment of psoriasis and includes topical dermal application of crude coal tar (containing polycyclic aromatic hydrocarbons) and exposure to UV-irradiation. The aim of the study was to evaluate contribution of GR to genotoxic risk and cellular stress in pediatric patients who represent a sensitive population subgroup. Decreasing of psoriasis area and severity index (PASI) score indicated higher likelihood of GR (p < 0.001). Significantly increased chromosomal aberrations (p < 0.001) and Hsp70 (p < 0.05) indicated higher genotoxic risk and cellular stress insensitive pediatric patients, immediately after GR. The Goeckerman regimen (GR) represents a local treatment of psoriasis and includes topical dermal application of crude coal tar (containing polycyclic aromatic hydrocarbons) and exposure to UV-irradiation. The aim of the study was to evaluate contribution of GR to genotoxic risk and cellular stress in pediatric patients who represent a sensitive population subgroup. Decreasing of psoriasis area and severity index (PASI) score indicated higher likelihood of GR (p < 0.001). Significantly increased chromosomal aberrations (p < 0.001) and Hsp70 (p < 0.05) indicated higher genotoxic risk and cellular stress insensitive pediatric patients, immediately after GR. (en)
Title	Genotoxic Hazard and Cellular Stress in Pediatric Patients Treated for Psoriasis with the Goeckerman Regimen Genotoxic Hazard and Cellular Stress in Pediatric Patients Treated for Psoriasis with the Goeckerman Regimen (en)
skos:prefLabel	Genotoxic Hazard and Cellular Stress in Pediatric Patients Treated for Psoriasis with the Goeckerman Regimen Genotoxic Hazard and Cellular Stress in Pediatric Patients Treated for Psoriasis with the Goeckerman Regimen (en)
skos:notation	RIV/00216208:11150/09:00208640!RIV10-MZ0-11150___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Ettler, Karel Krejsek, Jan Andrýs, Ctirad Fiala, Zdeněk Kremláček, Jan Borská, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	316214
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/09:00208640
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Genotoxic Hazard; Cellular Stress; Pediatric Patients; Psoriasis; Goeckerman Regimen (en)
http://linked.open.../riv/klicoveSlovo	Cellular Stress Genotoxic Hazard Pediatric Patients Psoriasis Goeckerman Regimen
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[AF853E21F4F9]
http://linked.open...i/riv/nazevZdroje	Pediatric Dermatology
http://linked.open...in/vavai/riv/obor	FM
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	26
http://linked.open...iv/tvurceVysledku	Andrýs, Ctirad Ettler, Karel Krejsek, Jan Kremláček, Jan Fiala, Zdeněk Borská, Lenka Hamáková, Květoslava Vellappally, Sajith Vimal, Jacob
http://linked.open...ain/vavai/riv/wos	000263466400004
http://linked.open...n/vavai/riv/zamer	Nové diagnostické indikátory a léčebné postupy v závislosti na různých obdobích života s důrazem na stáří
issn	0736-8046
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11150
is http://linked.open...avai/riv/vysledek of	Genotoxic Hazard and Cellular Stress in Pediatric Patients Treated for Psoriasis with the Goeckerman Regimen Genotoxic Hazard and Cellular Stress in Pediatric Patients Treated for Psoriasis with the Goeckerman Regimen Genotoxic Hazard and Cellular Stress in Pediatric Patients Treated for Psoriasis with the Goeckerman Regimen Genotoxic Hazard and Cellular Stress in Pediatric Patients Treated for Psoriasis with the Goeckerman Regimen

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