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  • The therapy with non-steroidal anti-inflammatory drugs is often accompanied with adverse effects in gastrointestinal tract. Aim of this experimental study was to define the time range of the creation of indomethacin-induced gastrointestinal lesions in rat. The gradual development of lesions was observed 6 hours in stomach and 24-72 hours in the intestine after the indomethacin administration. Not only the gradual development of pathophysiological alterations was observed but also the reparative phase (in the stomach). 24 hours seem to be advisable time suitable for the evaluation of the probiotics effecs as a potential therapy on the indomethacine-induced gastrointestinal lesions in rats.
  • The therapy with non-steroidal anti-inflammatory drugs is often accompanied with adverse effects in gastrointestinal tract. Aim of this experimental study was to define the time range of the creation of indomethacin-induced gastrointestinal lesions in rat. The gradual development of lesions was observed 6 hours in stomach and 24-72 hours in the intestine after the indomethacin administration. Not only the gradual development of pathophysiological alterations was observed but also the reparative phase (in the stomach). 24 hours seem to be advisable time suitable for the evaluation of the probiotics effecs as a potential therapy on the indomethacine-induced gastrointestinal lesions in rats. (en)
Title
  • Type and distribution of indomethacin-induced lesions in the gastrointestinal tract of rat
  • Type and distribution of indomethacin-induced lesions in the gastrointestinal tract of rat (en)
skos:prefLabel
  • Type and distribution of indomethacin-induced lesions in the gastrointestinal tract of rat
  • Type and distribution of indomethacin-induced lesions in the gastrointestinal tract of rat (en)
skos:notation
  • RIV/00216208:11150/09:00208621!RIV10-MZ0-11150___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA305/08/0535), Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika
  • Suppl. 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 347233
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11150/09:00208621
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • indomethacin; non-steroidal anti-inflammatory drugs; gastrointestinal lesions; rat; macroscopy/microscopy (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • SE - Švédské království
http://linked.open...ontrolniKodProRIV
  • [8AE5CC61EDC2]
http://linked.open...i/riv/nazevZdroje
  • Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 30
http://linked.open...iv/tvurceVysledku
  • Bureš, Jan
  • Kuneš, Martin
  • Květina, Jaroslav
http://linked.open...ain/vavai/riv/wos
  • 000275266600019
http://linked.open...n/vavai/riv/zamer
issn
  • 0172-780X
number of pages
http://localhost/t...ganizacniJednotka
  • 11150
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