About: High-risk human papillomavirus infection and p16INK4a protein expression in laryngeal lesions

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Celkem bylo analyzováno 88 laryngeálních lézí (23 zpěváckých uzlíků (VCNs), 23 papilomů (PAs), 18 dysplázií (DYs) a 24 karcinomů (CAs)), u kterých byla pomocí nepřímé imunohistochemie studována exprese proteinu p16INK4a (p16) a pomocí chromogenní in situ hybridizace (CISH) a polymerázové řetězové reakce (PCR) přítomnost vysoce rizikových lidských papilomavirů (HR-HPV). V expresi p16 a v přítomnosti HR-HPV DNA detekované pomocí CISH byl zaznamenán statisticky významný rozdíl mezi VCNs a PAs (p<0,000001). Senzitivita a specificita exprese p16 vzhledem k přítomnosti HR-HPV DNA stanovené pomocí CIHS byla 0,612 a 0,773.Naše studie potvrdila roli infekce HR-HPV v etiopatogenezi nejenom maligních, ale i benigních onemocněních laryngu. (cs) A total of 88 samples of laryngeal lesions (23 vocal cord nodules (VCNs), 23 papillomas (PAs), 18 dysplasias (DYs), and 24 carcinomas (CAs)) were analyzed for p16INK4a protein (p16) expression by immunohistochemistry and for high-risk human papillomavirus (HR-HPV) infection using chromogene in situ hybridization (CISH) and polymerase chain reaction (PCR). A statistically significant difference in p16 expression and HR-HPV DNA presence detected by CISH was observed between VCNs and PAs (p<0.000001). The sensitivity and specificity of p16 expression for HR-HPV DNA presence detected by CISH was 0.612 and 0.773, respectively.Our study confirms a potential role of HR-HPV infection not only in the pathogenesis of malignant, but also in benign laryngeal lesions. A total of 88 samples of laryngeal lesions (23 vocal cord nodules (VCNs), 23 papillomas (PAs), 18 dysplasias (DYs), and 24 carcinomas (CAs)) were analyzed for p16INK4a protein (p16) expression by immunohistochemistry and for high-risk human papillomavirus (HR-HPV) infection using chromogene in situ hybridization (CISH) and polymerase chain reaction (PCR). A statistically significant difference in p16 expression and HR-HPV DNA presence detected by CISH was observed between VCNs and PAs (p<0.000001). The sensitivity and specificity of p16 expression for HR-HPV DNA presence detected by CISH was 0.612 and 0.773, respectively.Our study confirms a potential role of HR-HPV infection not only in the pathogenesis of malignant, but also in benign laryngeal lesions. (en)
Title	High-risk human papillomavirus infection and p16INK4a protein expression in laryngeal lesions High-risk human papillomavirus infection and p16INK4a protein expression in laryngeal lesions (en) Infekce vysoce rizikovými lidskými papilomaviry a exprese proteinu p16INK4a v lézích hrtanu (cs)
skos:prefLabel	High-risk human papillomavirus infection and p16INK4a protein expression in laryngeal lesions High-risk human papillomavirus infection and p16INK4a protein expression in laryngeal lesions (en) Infekce vysoce rizikovými lidskými papilomaviry a exprese proteinu p16INK4a v lézích hrtanu (cs)
skos:notation	RIV/00216208:11150/08:00106937!RIV09-MZ0-11150___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Slaninka, Igor Ryška, Aleš Čelakovský, Petr Laco, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	370146
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/08:00106937
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	larynx; p16 protein; HPV; CISH; PCR (en)
http://linked.open.../riv/klicoveSlovo	larynx CISH p16 protein PCR HPV
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[A7BB0ACB6D7B]
http://linked.open...i/riv/nazevZdroje	Pathology Research and Practice
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	204
http://linked.open...iv/tvurceVysledku	Laco, Jan Ryška, Aleš Čelakovský, Petr Vošmiková, Hana Slaninka, Igor Jirásek, Michal
http://linked.open...ain/vavai/riv/wos	000258613100003
http://linked.open...n/vavai/riv/zamer	Nové diagnostické indikátory a léčebné postupy v závislosti na různých obdobích života s důrazem na stáří
issn	0344-0338
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11150
is http://linked.open...avai/riv/vysledek of	High-risk human papillomavirus infection and p16INK4a protein expression in laryngeal lesions High-risk human papillomavirus infection and p16INK4a protein expression in laryngeal lesions High-risk human papillomavirus infection and p16INK4a protein expression in laryngeal lesions High-risk human papillomavirus infection and p16INK4a protein expression in laryngeal lesions

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