About: In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity

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About: In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this study we examined the release kinetics of cTnT and cTnI using an in vitro model of NVCM and compared it with data from a model of anthracycline-induced cardiomyopathy in vivo. With 3 uM daunorubicin, the relative increase of AUC of cTnT and cTnI was 2.4 and 5.3-fold higher than the increase of LDH activity, respectively. In this study we examined the release kinetics of cTnT and cTnI using an in vitro model of NVCM and compared it with data from a model of anthracycline-induced cardiomyopathy in vivo. With 3 uM daunorubicin, the relative increase of AUC of cTnT and cTnI was 2.4 and 5.3-fold higher than the increase of LDH activity, respectively. (en) Studie se zabývá kinetikou uvolnění cTnT a cTnI na modelu NVCM in vitro a zároveň na modelu antracykliny-indukované kardiomyopatie in vivo. Při dávce 3 uM daunorubicinu se AUC pro cTnT zvýšila 2,4x a pro cTnI 5,3x ve srovnání s LDH. (cs)
Title	In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity Srdeční troponiny jako markery kardiotoxicity v pokusech in vitro a in vivo (cs) In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity (en)
skos:prefLabel	In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity Srdeční troponiny jako markery kardiotoxicity v pokusech in vitro a in vivo (cs) In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity (en)
skos:notation	RIV/00216208:11150/07:00003798!RIV08-MSM-11150___
http://linked.open.../vavai/riv/strany	218;228
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(GP305/05/P156), V, Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	1-3
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Geršl, Vladimír Štěrba, Martin Popelová, Olga Potáčová, Anna Adamcová, Michaela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	425847
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/07:00003798
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	drug-induced cardiotoxicity; anthracycline cardiotoxicity; daunorubicin; cardiac troponin I (cTnI); cardiac troponin T (cTnT) (en)
http://linked.open.../riv/klicoveSlovo	cardiac troponin I (cTnI) cardiac troponin T (cTnT) drug-induced cardiotoxicity anthracycline cardiotoxicity daunorubicin
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[85167E0B4C09]
http://linked.open...i/riv/nazevZdroje	Toxicology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of protective effects of novel iron chelators in the heart injury induced by oxidative stress and anthracycline cytostatics
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	237
http://linked.open...iv/tvurceVysledku	Adamcová, Michaela Geršl, Vladimír Popelová, Olga Štěrba, Martin Potáčová, Anna
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0300-483X
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	11150
is http://linked.open...avai/riv/vysledek of	In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity

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