About: Therapeutic Drug Monitoring (TDM) of Gentamicin in Critically ill Neonates

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Therapeutic Drug Monitoring (TDM) of Gentamicin in Critically ill Neonates Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Plazmatické koncentrace GE po první dávce umožňují predikovat ustálený stav koncentrací v prvním týdnu života u novorozenců bez kovariát, které významně modifikují farmakokinetiku GE. Nicméně Bland-Altmanova analýza ukazuje nesouhlas mezi predikovanými a změřenými koncentracemi GE u novorozenců, kterým byl podáván furosemid a/nebo se vyskytl syndrom úniku z kapilár. Nevysvětlitelný rozptyl mezi pozorovanými a předpovězenými hodnotami mohou být důsledkem současně podávaných léčiv nebo vážnějším klinickým stavem. Tato variabilita vyžaduje další výzkum. (cs) First dose plasma concentrations of GE in neonates during the first week of postnatal age seem to be predictive for steady state concentrations in neonates without co-variates significantly modifying pharmacokinetics of GE. However, the results of Bland-Altman analysis indicate a lack of agreement between predicted and monitored GE concentrations in neonates administered furosemide, and/or suffering from systemic capillary leak syndrome. The unexplained variability between observed and predicted values may originate from an effect of co-administered drugs and/or more serious clinical status of neonates. The variability requires further analysis. First dose plasma concentrations of GE in neonates during the first week of postnatal age seem to be predictive for steady state concentrations in neonates without co-variates significantly modifying pharmacokinetics of GE. However, the results of Bland-Altman analysis indicate a lack of agreement between predicted and monitored GE concentrations in neonates administered furosemide, and/or suffering from systemic capillary leak syndrome. The unexplained variability between observed and predicted values may originate from an effect of co-administered drugs and/or more serious clinical status of neonates. The variability requires further analysis. (en)
Title	Therapeutic Drug Monitoring (TDM) of Gentamicin in Critically ill Neonates Terapeutické monitorování gentamicinu u kriticky nemocných novorozenců (cs) Therapeutic Drug Monitoring (TDM) of Gentamicin in Critically ill Neonates (en)
skos:prefLabel	Therapeutic Drug Monitoring (TDM) of Gentamicin in Critically ill Neonates Terapeutické monitorování gentamicinu u kriticky nemocných novorozenců (cs) Therapeutic Drug Monitoring (TDM) of Gentamicin in Critically ill Neonates (en)
skos:notation	RIV/00216208:11150/07:00003696!RIV08-MZ0-11150___
http://linked.open.../vavai/riv/strany	84;85
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(1A8671)
http://linked.open...iv/cisloPeriodika	Suppl. 1
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Záhora, Jiří Martínková, Jiřina Selke - Krulichová, Iva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	455013
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/07:00003696
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	gentamicin; neonate; plasma level; pharmacokinetics (en)
http://linked.open.../riv/klicoveSlovo	gentamicin neonate pharmacokinetics plasma level
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[692A97CA9262]
http://linked.open...i/riv/nazevZdroje	Biomedical Papers of the Faculty of Medicine of Palacky University
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Pharmacokinetics of gentamicin, dosage prediction in term and preterm neonates
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	151
http://linked.open...iv/tvurceVysledku	Martínková, Jiřina Záhora, Jiří Selke-Krulichová, Iva
issn	1213-8118
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	11150
is http://linked.open...avai/riv/vysledek of	Therapeutic Drug Monitoring (TDM) of Gentamicin in Critically ill Neonates Therapeutic Drug Monitoring (TDM) of Gentamicin in Critically ill Neonates Therapeutic Drug Monitoring (TDM) of Gentamicin in Critically ill Neonates

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software