About: S-adenosylmethionine exerts a protective effect against thioacetamide-induced injury in primary cultures of rat hepatocytes     Goto   Sponge   NotDistinct   Permalink

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Description
  • S-adenosylmethionin(SAMe) vykazuje protektivní účinek na hepatocyty experimentálně poškozené thioacetamidem.Thioacetamid(TAA) je často používanou modelovou hepatotoxickou látkou navozující in vivo centrilubulární nekrózu.Cílem studie bylo odhalit protektivní mechanismy SAMe na hepatocytech poškozených TAA v primární kultuře.U hepatocytů inkubovaných 24 h s TAA současně se SAMe došlo ke snížení produkce LDH v závislosti na použité dávce SAMe.Inkubace se SAMe vedla i k útlumu lipoperoxidace navozené TAA a byl zmírněn pokles membránového potenciálu.Zmírnění poklesu GSH indukovaného inkubací s TAA bylo zaznamenáno v dalších časových intervalech po 48 a 72 h inkubace se SAMe.Příčinou může být zvýšení produkce GSH účinkem pokračující inkubace se SAMe. (cs)
  • S-adenosylmethionine(SAMe) was demonstrated to protect hepatocytes from toxic injury experimental induced in animals and isolated hepatocytes.Thioacetamide(TAA) is a frequently used model hepatotoxin causing in vivo centrilobular necrosis.The aim of our study was to determine the protective mechanisms of SAMe on TAA-induced hepatocyte injury using primary culture.The release of LDH from cells incubated with TAA for 24 h was lowered by contemporary treatment with SAMe for 24 h in a dose depdendent manner.The inhbibitory effect of SAMe on lipid peroxidation paralleled the effect on cytotoxicity.Decrease in mitochondrial membrane potential was prevented too.Attenuation of TAA-induced glutathione(GSH) depletion was determined at the following incubation periods of 48 and 72 h as a potential consequence of increase in GSH production during the continuation of SAMe treatment.
  • S-adenosylmethionine(SAMe) was demonstrated to protect hepatocytes from toxic injury experimental induced in animals and isolated hepatocytes.Thioacetamide(TAA) is a frequently used model hepatotoxin causing in vivo centrilobular necrosis.The aim of our study was to determine the protective mechanisms of SAMe on TAA-induced hepatocyte injury using primary culture.The release of LDH from cells incubated with TAA for 24 h was lowered by contemporary treatment with SAMe for 24 h in a dose depdendent manner.The inhbibitory effect of SAMe on lipid peroxidation paralleled the effect on cytotoxicity.Decrease in mitochondrial membrane potential was prevented too.Attenuation of TAA-induced glutathione(GSH) depletion was determined at the following incubation periods of 48 and 72 h as a potential consequence of increase in GSH production during the continuation of SAMe treatment. (en)
Title
  • S-adenosylmethionine exerts a protective effect against thioacetamide-induced injury in primary cultures of rat hepatocytes
  • S-adenosylmethionine exerts a protective effect against thioacetamide-induced injury in primary cultures of rat hepatocytes (en)
  • S-adenosylmethionin vykazuje protektivní účinek na thioacetamidem navozené poškození hepatocytů potkana v primární kultuře (cs)
skos:prefLabel
  • S-adenosylmethionine exerts a protective effect against thioacetamide-induced injury in primary cultures of rat hepatocytes
  • S-adenosylmethionine exerts a protective effect against thioacetamide-induced injury in primary cultures of rat hepatocytes (en)
  • S-adenosylmethionin vykazuje protektivní účinek na thioacetamidem navozené poškození hepatocytů potkana v primární kultuře (cs)
skos:notation
  • RIV/00216208:11150/07:00003620!RIV08-MSM-11150___
http://linked.open.../vavai/riv/strany
  • 363;371
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 448770
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11150/07:00003620
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • hepatocytes; mitochondria; S-adenosylmethionine; thioacetamide (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [C8B01EE92B92]
http://linked.open...i/riv/nazevZdroje
  • ATLA-Alternatives to Laboratory Animals
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 35
http://linked.open...iv/tvurceVysledku
  • Roušar, Tomáš
  • Kučera, Otto
  • Lotková, Halka
  • Červinková, Zuzana
  • Křiváková, Pavla
http://linked.open...n/vavai/riv/zamer
issn
  • 0261-1929
number of pages
http://localhost/t...ganizacniJednotka
  • 11150
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