About: Influence of azithromycin on hepatobiliary and renal excretion of methotrexate in rats

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Z výsledků předložené studie vyplývá, že azitromycin (AZT), substrát Mrp2, inhiboval in vitro a in vivo žlučovou i renální exkreci vysokodávkového methotrexátu (MTX). Na rozdíl od výsledků získaných ve studii s izolovanými hepatocyty, in vivo inhibice eliminace MTX nastala již při plazmatických koncentracích AZT, kterých je v klinické praxi běžně dosahováno. Z tohoto důvodu se interakce mezi AZT a MTX jeví jako klinicky významná. (cs) The present study reports that azithromycin (AZT), a substrate for Mrp2, inhibited the in vitro and in vivo biliary as well as renal excretion of high-dose methotrexate (MTX). In contrast to results of hepatocyte in vitro study, the in vivo inhibition of MTX elimination occured within the clinically achievable AZT concentrations. Therefore, the interaction between AZT and MTX can not be excluded in clinical settings. The present study reports that azithromycin (AZT), a substrate for Mrp2, inhibited the in vitro and in vivo biliary as well as renal excretion of high-dose methotrexate (MTX). In contrast to results of hepatocyte in vitro study, the in vivo inhibition of MTX elimination occured within the clinically achievable AZT concentrations. Therefore, the interaction between AZT and MTX can not be excluded in clinical settings. (en)
Title	Influence of azithromycin on hepatobiliary and renal excretion of methotrexate in rats Influence of azithromycin on hepatobiliary and renal excretion of methotrexate in rats (en) Vliv azitromycinu na hepatobiliární a renální exkreci metotrexátu u potkana (cs)
skos:prefLabel	Influence of azithromycin on hepatobiliary and renal excretion of methotrexate in rats Influence of azithromycin on hepatobiliary and renal excretion of methotrexate in rats (en) Vliv azitromycinu na hepatobiliární a renální exkreci metotrexátu u potkana (cs)
skos:notation	RIV/00216208:11150/07:00003536!RIV08-MSM-11150___
http://linked.open.../vavai/riv/strany	14;16
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1P05OC061), Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	Suppl. 1
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Hroch, Miloš Chládek, Jaroslav Kremláček, Jan Červinková, Zuzana Cermanová, Jolana Mičuda, Stanislav Martínková, Jiřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	426142
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/07:00003536
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	azithromycin; methotrexate; Mrp2 (en)
http://linked.open.../riv/klicoveSlovo	azithromycin Mrp2 methotrexate
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[D9B96A50BFB1]
http://linked.open...i/riv/nazevZdroje	Biomedical Papers of the Faculty of Medicine of Palacky University
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Physiologically based prediction of pharmacokinetics prior to in vivo studies: Focus on hepatic and renal drug elimination
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	151
http://linked.open...iv/tvurceVysledku	Chládek, Jaroslav Mičuda, Stanislav Lotková, Halka Červinková, Zuzana Hroch, Miloš Cermanová, Jolana Martínková, Jiřina
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	1213-8118
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	11150
is http://linked.open...avai/riv/vysledek of	Influence of azithromycin on hepatobiliary and renal excretion of methotrexate in rats Influence of azithromycin on hepatobiliary and renal excretion of methotrexate in rats Influence of azithromycin on hepatobiliary and renal excretion of methotrexate in rats

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